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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2003-10-31
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pubmed:abstractText |
HIV-1 protease inhibitors (PI) with an N-arylpyrrole moiety in the P(3) position afforded excellent antiviral potency and substantially improved aqueous solubility over previously reported variants. The rapid in vitro clearance of these compounds in human liver microsomes prompted oral coadministration with indinavir to hinder their metabolism by the cyctochrome P450 3A4 isozyme and allow for in vivo PK assessment.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:ChapmanKevin TKT,
pubmed-author:DuffyJoseph LJL,
pubmed-author:EminiEmilio AEA,
pubmed-author:JinLixiaL,
pubmed-author:KevinNancy JNJ,
pubmed-author:KirkBrian ABA,
pubmed-author:KuoLawrence CLC,
pubmed-author:LinJiunn HJH,
pubmed-author:OlsenDavid BDB,
pubmed-author:RutkowskiCarrie ACA,
pubmed-author:SchleifWilliam AWA,
pubmed-author:StahlhutMarkM,
pubmed-author:TataJames RJR
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4027-30
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:14592500-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:14592500-Administration, Oral,
pubmed-meshheading:14592500-Biotransformation,
pubmed-meshheading:14592500-Cytochrome P-450 CYP2D6,
pubmed-meshheading:14592500-Cytochrome P-450 CYP3A,
pubmed-meshheading:14592500-Cytochrome P-450 Enzyme System,
pubmed-meshheading:14592500-Drug Design,
pubmed-meshheading:14592500-Drug Resistance, Viral,
pubmed-meshheading:14592500-Drug Therapy, Combination,
pubmed-meshheading:14592500-HIV Protease,
pubmed-meshheading:14592500-HIV Protease Inhibitors,
pubmed-meshheading:14592500-HIV-1,
pubmed-meshheading:14592500-Humans,
pubmed-meshheading:14592500-Indinavir,
pubmed-meshheading:14592500-Microsomes, Liver,
pubmed-meshheading:14592500-Pyrroles,
pubmed-meshheading:14592500-Structure-Activity Relationship
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pubmed:year |
2003
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pubmed:articleTitle |
Novel HIV-1 protease inhibitors active against multiple PI-resistant viral strains: coadministration with indinavir.
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pubmed:affiliation |
Department of Basic Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.
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pubmed:publicationType |
Journal Article
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