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14592473
Source:
http://linkedlifedata.com/resource/pubmed/id/14592473
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Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0019643
,
umls-concept:C0022634
,
umls-concept:C0243077
pubmed:issue
22
pubmed:dateCreated
2003-10-31
pubmed:abstractText
Several heterocyclic ketones were investigated as potential inhibitors of histone deacetylase. Nanomolar inhibitors such as 22 and 25 were obtained, the anti-proliferative activity of which were shown to be mediated by HDAC inhibition.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors
,
http://linkedlifedata.com/resource/pubmed/chemical/Heterocyclic Compounds
,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylase Inhibitors
,
http://linkedlifedata.com/resource/pubmed/chemical/Ketones
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0960-894X
pubmed:author
pubmed-author:BouskaJennifer JJJ
,
pubmed-author:CurtinMichael LML
,
pubmed-author:DavidsenSteven KSK
,
pubmed-author:FreyRobin RRR
,
pubmed-author:GlaserKeith BKB
,
pubmed-author:GoyM FMF
,
pubmed-author:HeymanH RobinHR
,
pubmed-author:JiZhiqinZ
,
pubmed-author:LiJunlingJ
,
pubmed-author:MarcottePatrick APA
,
pubmed-author:MichaelidesMichael RMR
,
pubmed-author:PeaseLoriL
,
pubmed-author:RaoD CDC
,
pubmed-author:SteinmanDouglasD
,
pubmed-author:VasudevanAnilA
,
pubmed-author:WadaCarol KCK
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3909-13
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:14592473-Enzyme Inhibitors
,
pubmed-meshheading:14592473-Heterocyclic Compounds
,
pubmed-meshheading:14592473-Histone Deacetylase Inhibitors
,
pubmed-meshheading:14592473-Ketones
,
pubmed-meshheading:14592473-Kinetics
,
pubmed-meshheading:14592473-Structure-Activity Relationship
pubmed:year
2003
pubmed:articleTitle
Heterocyclic ketones as inhibitors of histone deacetylase.
pubmed:affiliation
Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. anil.vasudevan@abbott.com
pubmed:publicationType
Journal Article