Linked Life Data

14586399

Source:http://linkedlifedata.com/resource/pubmed/id/14586399

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
49
pubmed:dateCreated
2003-10-30
pubmed:abstractText
Recurrent chromosome 12p deletions are associated with distinct tumor types and suggest the presence of a tumor suppressor gene (TSG). Previously, we mapped an EST with similarity to a protein tyrosine phosphatase to the minimally deleted region for all these neoplasms. The corresponding gene, DUSP16/MKP-7, was recently shown to code for a mitogen-activated protein kinase phosphatase, suggestive for a function as tumor suppressor. Overexpression of DUSP16 in BCR-ABL-transformed Rat-1 fibroblasts reduces their transforming capacity in vitro and in vivo via downregulation of BCR-ABL-induced JNK activation. A role for DUSP16 as a regulator of JNK signaling was further demonstrated via overexpression in Ba/F3 cells, which increased their antiapoptosis. However, no inactivating mutations could be detected in leukemia patients hemizygous for DUSP16, and the effect of hemizygosity on DUSP16 expression level could not be assessed due to the variability of DUSP16 transcript levels observed in leukaemia cell lines and in patients. Taken together, the functional data point to a context-dependent role for DUSP16 on cell transformation and apoptosis, reflecting the dual role of JNK, and therefore suggest that DUSP16 might be haploinsufficient for tumor suppression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0950-9232
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7728-36
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:14586399-Animals, pubmed-meshheading:14586399-Cell Transformation, Neoplastic, pubmed-meshheading:14586399-Chromosomes, Human, Pair 12, pubmed-meshheading:14586399-Dual-Specificity Phosphatases, pubmed-meshheading:14586399-Genes, Tumor Suppressor, pubmed-meshheading:14586399-Genes, abl, pubmed-meshheading:14586399-Humans, pubmed-meshheading:14586399-JNK Mitogen-Activated Protein Kinases, pubmed-meshheading:14586399-Leukemia, pubmed-meshheading:14586399-Loss of Heterozygosity, pubmed-meshheading:14586399-Mitogen-Activated Protein Kinase Phosphatases, pubmed-meshheading:14586399-Mitogen-Activated Protein Kinases, pubmed-meshheading:14586399-Neoplasms, pubmed-meshheading:14586399-Protein Tyrosine Phosphatases, pubmed-meshheading:14586399-Rats, pubmed-meshheading:14586399-p38 Mitogen-Activated Protein Kinases
pubmed:year
2003
pubmed:articleTitle
MAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for chromosome region 12p12-13, reduces BCR-ABL-induced transformation.
pubmed:affiliation
Human Genome Laboratory, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't