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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-10-30
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pubmed:abstractText |
The MDR1 gene encodes the efflux transporter P-glycoprotein, which is highly expressed in the small intestine and in the blood-brain barrier. A major function of P-glycoprotein is to limit the absorption and central nervous system exposure of numerous xenobiotics. A genetic polymorphism in the MDR1 gene (C3435T) has been associated with changes in the intestinal expression level and function of P-glycoprotein. The aim of this study was to investigate the effect of this polymorphism on disposition and brain entry of the P-glycoprotein substrate loperamide.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0009-9236
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
487-98
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14586389-Adult,
pubmed-meshheading:14586389-Antidiarrheals,
pubmed-meshheading:14586389-Area Under Curve,
pubmed-meshheading:14586389-Biotransformation,
pubmed-meshheading:14586389-Carbon Dioxide,
pubmed-meshheading:14586389-Central Nervous System,
pubmed-meshheading:14586389-Depression, Chemical,
pubmed-meshheading:14586389-Female,
pubmed-meshheading:14586389-Genes, MDR,
pubmed-meshheading:14586389-Genotype,
pubmed-meshheading:14586389-Haplotypes,
pubmed-meshheading:14586389-Humans,
pubmed-meshheading:14586389-Intestinal Absorption,
pubmed-meshheading:14586389-Loperamide,
pubmed-meshheading:14586389-Male,
pubmed-meshheading:14586389-Middle Aged,
pubmed-meshheading:14586389-P-Glycoprotein,
pubmed-meshheading:14586389-Respiratory Mechanics
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pubmed:year |
2003
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pubmed:articleTitle |
No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects.
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pubmed:affiliation |
Department of Biopharmaceutical Sciences, University of California, San Francisco, CA 94143-0446, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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