Source:http://linkedlifedata.com/resource/pubmed/id/14586029
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2004-2-19
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pubmed:abstractText |
We examined prefrontal neuronal activity while monkeys performed a sequential target-shift task, in which, after a positional cue indicated the initial saccade target among 8 peripheral positions, the monkeys were required to internally shift the target by one position on every flash of a target-shift cue. The target-shift cue appeared in the center 0 to 3 times within a single trial and was always the same in shape, size, and color. We found selective neuronal activity related to the target position: when the target-shift cue implied the target shift to particular peripheral positions, neurons exhibited early-dominant and late-dominant activity during the following delay period. The early-dominant target-selective activity emerged early in the delay just after the presentation of the target-shift cue, whereas the late-dominant activity gradually built up toward the end of the delay. Because the target-shift cue was not related to any specific target location, the early-dominant target-selective activity could not be a mere visual response to the target-shift cue. We suggest that the early-dominant activity reflects the transitory representation for the saccade target that was triggered by the nonspatial target-shift cue, whereas the late-dominant activity reflects the target representation in the spatial working memory or the preparatory set for the possible impending saccade, being repeatedly updated during sequential target shifts.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-3077
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1367-80
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14586029-Animals,
pubmed-meshheading:14586029-Cues,
pubmed-meshheading:14586029-Databases, Factual,
pubmed-meshheading:14586029-Electrodes, Implanted,
pubmed-meshheading:14586029-Functional Laterality,
pubmed-meshheading:14586029-Macaca,
pubmed-meshheading:14586029-Memory, Short-Term,
pubmed-meshheading:14586029-Neurons,
pubmed-meshheading:14586029-Population,
pubmed-meshheading:14586029-Prefrontal Cortex,
pubmed-meshheading:14586029-Psychomotor Performance,
pubmed-meshheading:14586029-Regression Analysis,
pubmed-meshheading:14586029-Saccades,
pubmed-meshheading:14586029-Space Perception
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pubmed:year |
2004
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pubmed:articleTitle |
Prefrontal neuronal activity encodes spatial target representations sequentially updated after nonspatial target-shift cues.
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pubmed:affiliation |
Department of Physiology, The University of Tokyo School of Medicine, Tokyo 113-0033, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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