Linked Life Data

14585604

Source:http://linkedlifedata.com/resource/pubmed/id/14585604

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2003-10-30
pubmed:abstractText
Feedforward inhibitory circuits are involved both in the suppression of excitability and timing of action potential generation in principal cells. In the CA3 hippocampus, a single mossy fiber from a dentate gyrus granule cell forms giant boutons with multiple release sites, which are capable of detonating CA3 principal cells. By contrast, mossy fiber terminals form a larger number of Lilliputian-sized synapses with few release sites onto local circuit interneurons, with distinct presynaptic and postsynaptic properties. This dichotomy between the two synapse types endows the circuit with exquisite control over pyramidal cell discharge. Under pathological conditions where feedforward inhibition is compromised, focal excitation is no longer contained, rendering the circuit susceptible to hyperexcitability.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0166-2236
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
631-40
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Interneuron diversity series: containing the detonation--feedforward inhibition in the CA3 hippocampus.
pubmed:affiliation
Laboratory on Cellular and Synaptic Physiology, Building 49, Room 5A72, NICHD-LCSN, Bethesda, MD 20892, USA.
pubmed:publicationType
Journal Article, Review