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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2003-10-30
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pubmed:abstractText |
(E)-3-(Benzenesulfonyl)-2-(methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine (7) was found to be a potent and selective 5-HT(6) antagonist. A one-step synthesis of this compound is described.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-2623
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pubmed:author |
pubmed-author:BertekapRobert LRL,
pubmed-author:Grant-YoungKatharineK,
pubmed-author:HeHuanH,
pubmed-author:HuShuanghuaS,
pubmed-author:HuangYazhongY,
pubmed-author:HugWW,
pubmed-author:KlakouskiCherylC,
pubmed-author:LiYiY,
pubmed-author:ScolaPaul MPM,
pubmed-author:WestphalRyan SRS,
pubmed-author:WuDedongD,
pubmed-author:WuYong-JinYJ
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4834-7
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:14584934-Acrylonitrile,
pubmed-meshheading:14584934-Calcium,
pubmed-meshheading:14584934-Cell Line,
pubmed-meshheading:14584934-Crystallography, X-Ray,
pubmed-meshheading:14584934-Cytochrome P-450 Enzyme System,
pubmed-meshheading:14584934-Humans,
pubmed-meshheading:14584934-Models, Molecular,
pubmed-meshheading:14584934-Pyrimidines,
pubmed-meshheading:14584934-Receptors, Serotonin,
pubmed-meshheading:14584934-Serotonin Antagonists,
pubmed-meshheading:14584934-Structure-Activity Relationship,
pubmed-meshheading:14584934-Sulfones
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pubmed:year |
2003
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pubmed:articleTitle |
Identification of a potent and selective 5-HT(6) antagonist: one-step synthesis of (E)-3-(benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile.
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pubmed:affiliation |
Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA. yong-jin.wu@bms.com
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pubmed:publicationType |
Journal Article
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