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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-10-29
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pubmed:abstractText |
Accumulated evidence supports that both Id helix-loop-helix proteins and derivatives of vitamin A, retinoids, play a pivotal role in the regulation of cell growth and differentiation. We analyzed the effects of all-trans retinoic acid (atRA) on the gene and protein expression of Id2 in THP-1 cells and found a suppression of the levels of Id2. The down-regulation was abolished towards a constitutively expressed level of Id2 mRNA. The decreased level of Id2 was associated with growth suppression and does support the prevalent conception of the action of Id2 as a stimulator of cell growth.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0392-9078
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
471-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14582708-Cell Differentiation,
pubmed-meshheading:14582708-Cell Line, Tumor,
pubmed-meshheading:14582708-DNA-Binding Proteins,
pubmed-meshheading:14582708-Down-Regulation,
pubmed-meshheading:14582708-Gene Expression Regulation, Leukemic,
pubmed-meshheading:14582708-Humans,
pubmed-meshheading:14582708-Inhibitor of Differentiation Protein 2,
pubmed-meshheading:14582708-RNA, Messenger,
pubmed-meshheading:14582708-Repressor Proteins,
pubmed-meshheading:14582708-Time Factors,
pubmed-meshheading:14582708-Transcription Factors,
pubmed-meshheading:14582708-Tretinoin
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pubmed:year |
2003
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pubmed:articleTitle |
Down-regulation of ID2 by all-trans retinoic acid in monocytic leukemia cells (THP-1).
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pubmed:affiliation |
Division of Biomedicine, Department of Caring Sciences, University of Orebro, Orebro, Sweden. Dick.Wagsater@ivo.oru.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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