Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
2003-10-28
pubmed:abstractText
Canine parvovirus (CPV) and feline panleukopenia virus (FPV) differ in their ability to infect dogs and dog cells. Canine cell infection is a specific property of CPV and depends on the ability of the virus to bind the canine transferrin receptor (TfR), as well as other unidentified factors. Three regions in the capsid structure, located around VP2 residues 93, 300, and 323, can all influence canine TfR binding and canine cell infection. These regions were compared in the CPV and FPV capsid structures that have been determined, as well as in two new structures of CPV capsids that contain substitutions of the VP2 Asn-93 to Asp and Arg, respectively. The new structures, determined by X-ray crystallography to 3.2 and 3.3 A resolutions, respectively, clearly showed differences in the interactions of residue 93 with an adjacent loop on the capsid surface. Each of the three regions show small differences in structure, but each appears to be structurally independent of the others, and the changes likely act together to affect the ability of the capsid to bind the canine TfR and to infect canine cells. This emphasizes the complex nature of capsid alterations that change the virus-cell interaction to allow infection of cells from different hosts.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-10089341, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-10531064, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-10638746, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-10884355, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-11264378, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-11533189, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-11827486, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-12136130, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-12525605, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-12885908, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-1322591, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-1331498, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-15299374, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-1616694, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-1647068, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-1942246, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-2006420, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-2174243, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-3176341, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-5700707, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-7513918, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-7645206, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-8207398, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-8259653, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-8392729, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-8560765, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-8642680, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-8918534, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-9130694, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-9371580, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-9420281, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-9573224, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-9757107, http://linkedlifedata.com/resource/pubmed/commentcorrection/14581558-9817841
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
12211-21
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Structures of host range-controlling regions of the capsids of canine and feline parvoviruses and mutants.
pubmed:affiliation
Department of Biochemistry and Molecular Biology, Center for Structural Biology, College of Medicine, University of Florida, Gainesville, Florida 32610, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.