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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2003-10-28
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pubmed:abstractText |
Antisense approaches targeting the epidermal growth factor receptor (EGFR) have been demonstrated to inhibit the growth of squamous cell carcinoma of the head and neck (SCCHN). Docetaxel is an effective chemotherapeutic agent in the treatment of SCCHN. The present study was undertaken to evaluate the antitumor mechanisms of EGFR antisense (AS) oligonucleotides administered in combination with docetaxel in preclinical models of SCCHN.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/Coloring Agents,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Stat3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Taxoids,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazolium Salts,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/docetaxel,
http://linkedlifedata.com/resource/pubmed/chemical/thiazolyl blue
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5028-35
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14581378-Animals,
pubmed-meshheading:14581378-Antineoplastic Agents,
pubmed-meshheading:14581378-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:14581378-Blotting, Western,
pubmed-meshheading:14581378-Carcinoma, Squamous Cell,
pubmed-meshheading:14581378-Cell Division,
pubmed-meshheading:14581378-Cell Line, Tumor,
pubmed-meshheading:14581378-Coloring Agents,
pubmed-meshheading:14581378-DNA-Binding Proteins,
pubmed-meshheading:14581378-Dose-Response Relationship, Drug,
pubmed-meshheading:14581378-Down-Regulation,
pubmed-meshheading:14581378-Female,
pubmed-meshheading:14581378-Head and Neck Neoplasms,
pubmed-meshheading:14581378-Humans,
pubmed-meshheading:14581378-Inhibitory Concentration 50,
pubmed-meshheading:14581378-Mice,
pubmed-meshheading:14581378-Mice, Nude,
pubmed-meshheading:14581378-Neoplasm Transplantation,
pubmed-meshheading:14581378-Oligonucleotides, Antisense,
pubmed-meshheading:14581378-Phosphotyrosine,
pubmed-meshheading:14581378-Receptor, Epidermal Growth Factor,
pubmed-meshheading:14581378-STAT3 Transcription Factor,
pubmed-meshheading:14581378-Signal Transduction,
pubmed-meshheading:14581378-Taxoids,
pubmed-meshheading:14581378-Tetrazolium Salts,
pubmed-meshheading:14581378-Thiazoles,
pubmed-meshheading:14581378-Time Factors,
pubmed-meshheading:14581378-Trans-Activators,
pubmed-meshheading:14581378-Vascular Endothelial Growth Factor A
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pubmed:year |
2003
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pubmed:articleTitle |
Antitumor effects of epidermal growth factor receptor antisense oligonucleotides in combination with docetaxel in squamous cell carcinoma of the head and neck.
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pubmed:affiliation |
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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