14581344

Source:http://linkedlifedata.com/resource/pubmed/id/14581344

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0009429, umls-concept:C0014442, umls-concept:C0208973, umls-concept:C0441655, umls-concept:C0556895, umls-concept:C0596581, umls-concept:C0671970, umls-concept:C0879396, umls-concept:C0919281, umls-concept:C1517892, umls-concept:C1527178, umls-concept:C1554080, umls-concept:C1704666, umls-concept:C1706198
pubmed:issue	13
pubmed:dateCreated	2003-10-28
pubmed:abstractText	The efficacy of new oral fluoropyrimidines, including capecitabine, is improved in cells expressing high levels of thymidine phosphorylase (TP) and low levels of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase. We used a human head and neck cancer cell line (CAL33) to examine the influence of cell cycle modifications on TS, TP, and dihydropyrimidine dehydrogenase activity.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9502500
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/5-fluoropyrimidine, http://linkedlifedata.com/resource/pubmed/chemical/Antimetabolites, Antineoplastic, http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers, http://linkedlifedata.com/resource/pubmed/chemical/Deoxycytidine, http://linkedlifedata.com/resource/pubmed/chemical/Floxuridine, http://linkedlifedata.com/resource/pubmed/chemical/Fluorouracil, http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines, http://linkedlifedata.com/resource/pubmed/chemical/Quinazolines, http://linkedlifedata.com/resource/pubmed/chemical/RNA, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/capecitabine, http://linkedlifedata.com/resource/pubmed/chemical/doxifluridine, http://linkedlifedata.com/resource/pubmed/chemical/gefitinib
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	1078-0432
pubmed:author	pubmed-author:CiccoliniJosephJ, pubmed-author:DubreuilAlainA, pubmed-author:EtienneMarie-ChristineMC, pubmed-author:FischelJean-LouisJL, pubmed-author:FormentoJean-LouisJL, pubmed-author:FormentoPatriciaP, pubmed-author:MagnéNicolasN, pubmed-author:MarchettiSandrineS, pubmed-author:MilanoGérardG, pubmed-author:RenéeNicoleN, pubmed-author:TiffonCélineC
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	9
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	4735-42
pubmed:dateRevised	2007-11-15
pubmed:meshHeading	pubmed-meshheading:14581344-Administration, Oral, pubmed-meshheading:14581344-Antimetabolites, Antineoplastic, pubmed-meshheading:14581344-Antineoplastic Agents, pubmed-meshheading:14581344-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:14581344-Cell Cycle, pubmed-meshheading:14581344-Cell Division, pubmed-meshheading:14581344-Cell Line, Tumor, pubmed-meshheading:14581344-Cell Survival, pubmed-meshheading:14581344-DNA Primers, pubmed-meshheading:14581344-Deoxycytidine, pubmed-meshheading:14581344-Floxuridine, pubmed-meshheading:14581344-Fluorouracil, pubmed-meshheading:14581344-Head and Neck Neoplasms, pubmed-meshheading:14581344-Humans, pubmed-meshheading:14581344-Models, Chemical, pubmed-meshheading:14581344-Polymerase Chain Reaction, pubmed-meshheading:14581344-Pyrimidines, pubmed-meshheading:14581344-Quinazolines, pubmed-meshheading:14581344-RNA, pubmed-meshheading:14581344-RNA, Messenger, pubmed-meshheading:14581344-Time Factors, pubmed-meshheading:14581344-Transcription, Genetic
pubmed:year	2003
pubmed:articleTitle	ZD1839 (Iressa) modifies the activity of key enzymes linked to fluoropyrimidine activity: rational basis for a new combination therapy with capecitabine.
pubmed:affiliation	Oncopharmacology Unit, Centre Antoine Lacassagne, 06189 Nice Cedex 2, France.
pubmed:publicationType	Journal Article