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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4-5
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pubmed:dateCreated |
2003-10-27
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pubmed:abstractText |
NKB1 inhibits cytoxic activity of T lymphocytes mediated by superantigens, which is one of the contributing factors in the pathogenesis of rheumatoid arthritis (RA). In this study, we determined the expression of NKB1 on peripheral blood T cells in patients with RA. Our findings revealed that among patients with RA, NKB1(+) CD8(+ )T cells decreased significantly in comparison to controls (ratio: P < 0.05; absolute number: P < 0.005), and this decrease was not related to or influenced by HLA-Bw4 as a ligand of NKB1. This result may suggest that decreased expression of NKB1(+) CD8(+ )T cells contributes to the pathogenesis of RA mediated by the activation of CD8(+) T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0770-3198
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
305-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:14579161-Adult,
pubmed-meshheading:14579161-Aged,
pubmed-meshheading:14579161-Aged, 80 and over,
pubmed-meshheading:14579161-Antigens, CD4,
pubmed-meshheading:14579161-Arthritis, Rheumatoid,
pubmed-meshheading:14579161-Biological Markers,
pubmed-meshheading:14579161-Case-Control Studies,
pubmed-meshheading:14579161-Cohort Studies,
pubmed-meshheading:14579161-Female,
pubmed-meshheading:14579161-HLA-B Antigens,
pubmed-meshheading:14579161-Humans,
pubmed-meshheading:14579161-Lupus Erythematosus, Systemic,
pubmed-meshheading:14579161-Male,
pubmed-meshheading:14579161-Middle Aged,
pubmed-meshheading:14579161-Probability,
pubmed-meshheading:14579161-Prognosis,
pubmed-meshheading:14579161-Receptors, Immunologic,
pubmed-meshheading:14579161-Receptors, KIR,
pubmed-meshheading:14579161-Receptors, KIR3DL1,
pubmed-meshheading:14579161-Reference Values,
pubmed-meshheading:14579161-Sensitivity and Specificity,
pubmed-meshheading:14579161-Severity of Illness Index,
pubmed-meshheading:14579161-Statistics, Nonparametric
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pubmed:year |
2003
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pubmed:articleTitle |
Expression of NKB1 on peripheral T cells in patients with rheumatoid arthritis.
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pubmed:affiliation |
Juntendo University School of Medicine, Tokyo, Japan. mayuta@hkg.odn.ne.jp
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pubmed:publicationType |
Journal Article,
Comparative Study
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