Linked Life Data

1457808

Source:http://linkedlifedata.com/resource/pubmed/id/1457808

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-1-8
pubmed:abstractText
GRP78, a 78-kDa protein localized in the endoplasmic reticulum, is a member of the HSP70 protein family. However, unlike hsp70 which is intronless and belongs to a multigene family, grp78 is a single copy gene and contains intervening sequences. In this aspect, the grp78 gene resembles more closely that of the constitutively expressed heat shock cognate gene, hsc73. In this report, we compare the grp78 and hsc73 genes and show that: (1) the intron/exon junctions of the two genes are not conserved, but occur at similar positions; (2) while the protein sequences are highly conserved, being 62% identical, the conservation is concentrated at discrete regions over the N-terminal three-fourths of the protein; (3) this conservation represents the ATP binding and structural domains shared among the members of the HSP70 family; (4) the C-terminus is highly divergent and likely represents domains specific for the individual family members; and (5) sequences partially homologous to the grp78 5' UTR and signal sequence, which targets GRP78 into the ER, are found within an additional first intron of hsc73. The evolutionary implications of these two genes are discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1042-5179
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:geneSymbol
grp78, hsc73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
41-8
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Comparison of the genomic organizations of the rat grp78 and hsc73 gene and their evolutionary implications.
pubmed:affiliation
Department of Biochemistry, University of Southern California School of Medicine, Los Angeles.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.