Linked Life Data

14577694

Source:http://linkedlifedata.com/resource/pubmed/id/14577694

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-10-27
pubmed:abstractText
7,8-Dihydroxyflavanone, isolated from the seeds of Alpinia Katsumadai Hayata, showed an inhibitory effect on Jun-Fos dimer action. 7,8-Dihydroxyflavanone blocked the action of the dimer on a DNA consensus sequence, the AP-1 binding site. We have concluded that the Jun-Fos heterodimer, bound with 7,8-dihydroxyflavanone, cannot bind to the AP-1 site and therefore results in signal interruption. The 7,8-dihydroxyflavanone was also found to have an in vitro cytotoxic effect against A549 (a human lung cancer cell line) and K562 (a human leukemia cell line).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1478-6419
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
431-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
7, 8-dihydroxyflavanone as an inhibitor for Jun-Fos-DNA complex formation and its cytotoxic effect on cultured human cancer cells.
pubmed:affiliation
School of Chemistry and Molecular Engineering, College of Natural Sciences, Seoul National University, San 56-1, Shillim-dong, Kwanak-gu, Seoul, 151-742, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't