Linked Life Data

14577128

Source:http://linkedlifedata.com/resource/pubmed/id/14577128

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-10-27
pubmed:abstractText
The expression of 82 cell surface molecules was analysed on pathological cells from 52 patients with acute lymphoblastic leukemia (T and B), acute myeloid leukemia (FAB: M0, M1, M2, M3, M4, M5), chronic myeloid leukemia, chronic myelo-monocytic leukemia) and non Hodgkin's lymphoma (T and B types). We have selected patients with a high leukocyte count and percentage of blasts. Staining for membrane molecules was done by the immunofluorescence method and evaluated by flow cytometry. The findings indicate that expression of membrane molecules on pathological cells is quantitatively and qualitatively different in individual cases. The leukemia/lymphoma cells in their crude from represent the main phenotypes of normal haematopoietic cells, which reveal the great diversity of immunophenotypes within the main functional characterization of blood malignancies. The immunophenotype heterogeneity of leukemic cells has proved to be much greater than the match with existing classification criteria, this fact could raise the necessity for further functional evaluation and specification of immunophenotyping of the leukemia/lymphoma cells. The concept of explanation of pathogenesis and pathophysiology of different types of leukemia/lymphoma cells on the basis that they are derived from normal haematopoiesis must be accepted, because the number of membrane markers and their functional properties are correspondingly convincing.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0036-5327
pubmed:author
pubmed:issnType
Print
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
183-97
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
The interaction and functional properties of leukocyte molecules of human leukemia/lymphoma cells.
pubmed:affiliation
Institute of Haematology and Blood Transfusion, Clinical Department, U Nemocnice 1, 128 20 Prague 2, Czech Republic.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't