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rdf:type |
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lifeskim:mentions |
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0023690,
umls-concept:C0027740,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0458247,
umls-concept:C0521329,
umls-concept:C1157324,
umls-concept:C1292733,
umls-concept:C1527148
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pubmed:issue |
5
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pubmed:dateCreated |
2003-10-24
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pubmed:abstractText |
Prostaglandins, synthesized in the spinal cord in response to noxious stimuli, are known to facilitate nociceptive transmission, raising questions about their role in neuropathic pain. The current study tested the hypothesis that spinal nerve ligation-induced allodynia is composed of an early prostaglandin-dependent phase, the disruption of which prevents allodynia.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0003-3022
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1180-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14576557-Animals,
pubmed-meshheading:14576557-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:14576557-Dinoprostone,
pubmed-meshheading:14576557-Glutamic Acid,
pubmed-meshheading:14576557-Ibuprofen,
pubmed-meshheading:14576557-Injections, Spinal,
pubmed-meshheading:14576557-Ligation,
pubmed-meshheading:14576557-Male,
pubmed-meshheading:14576557-Microdialysis,
pubmed-meshheading:14576557-Pain,
pubmed-meshheading:14576557-Pain Measurement,
pubmed-meshheading:14576557-Physical Stimulation,
pubmed-meshheading:14576557-Prostaglandin Antagonists,
pubmed-meshheading:14576557-Prostaglandins,
pubmed-meshheading:14576557-Pyrazoles,
pubmed-meshheading:14576557-Rats,
pubmed-meshheading:14576557-Rats, Sprague-Dawley,
pubmed-meshheading:14576557-Spinal Nerves
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pubmed:year |
2003
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pubmed:articleTitle |
Inhibition of spinal prostaglandin synthesis early after L5/L6 nerve ligation prevents the development of prostaglandin-dependent and prostaglandin-independent allodynia in the rat.
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pubmed:affiliation |
Division of Basic Medical Sciences, Faculty of Medicine, and School of Pharmacy, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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