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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2003-10-24
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pubmed:abstractText |
Eighteen month old spontaneously hypertensive rats (SHR-rats) showed myocardial dysfunction and autoantibodies directed against the beta1-adrenoceptor similarly as known in human dilated cardiomyopathy or Chagas' disease. The agonist-like antibodies were able to activate the beta1-adrenoceptor mediated signal transduction cascade in cultured rat cardiomyocytes and induced a long-lasting stimulatory effect resulting in a harmful adrenergic overdrive. The antibodies recognized an epitope of the second extracellular loop of the beta1-adrenoceptor identical to that epitope identified in Chagas' disease. In conclusion, our assumption is supported that old SHR-rat are an useful animal model for investigating the role of anti-beta1-adrenoceptor antibodies in the induction of human cardiomyopathy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/ICI 118551,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Propanolamines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-1,
http://linkedlifedata.com/resource/pubmed/chemical/Thionucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/adenosine-3',5'-cyclic...
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0300-8177
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
251
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
67-75
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14575306-Adrenergic beta-Antagonists,
pubmed-meshheading:14575306-Aging,
pubmed-meshheading:14575306-Animals,
pubmed-meshheading:14575306-Animals, Newborn,
pubmed-meshheading:14575306-Autoantibodies,
pubmed-meshheading:14575306-Blood Pressure,
pubmed-meshheading:14575306-Cardiomyopathies,
pubmed-meshheading:14575306-Cells, Cultured,
pubmed-meshheading:14575306-Cyclic AMP,
pubmed-meshheading:14575306-Epitopes,
pubmed-meshheading:14575306-Heart Rate,
pubmed-meshheading:14575306-Humans,
pubmed-meshheading:14575306-Immunoglobulins,
pubmed-meshheading:14575306-Myocytes, Cardiac,
pubmed-meshheading:14575306-Peptides,
pubmed-meshheading:14575306-Propanolamines,
pubmed-meshheading:14575306-Rats,
pubmed-meshheading:14575306-Rats, Inbred SHR,
pubmed-meshheading:14575306-Rats, Inbred WKY,
pubmed-meshheading:14575306-Receptors, Adrenergic, beta-1,
pubmed-meshheading:14575306-Signal Transduction,
pubmed-meshheading:14575306-Thionucleotides,
pubmed-meshheading:14575306-Ventricular Pressure
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pubmed:year |
2003
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pubmed:articleTitle |
Functional and structural characterization of anti-beta1-adrenoceptor autoantibodies of spontaneously hypertensive rats.
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pubmed:affiliation |
Max Delbrück Centrum für Molekulare Medizin, Berlin, Germany. gwalluk@mdc.berlin.de
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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