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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2003-10-23
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pubmed:abstractText |
Interleukin-12 (IL-12) has been inversely associated with disease severity in human and murine malaria, and a polymorphism in the IL-12 p40 subunit gene (IL12B) has been associated with susceptibility to human cerebral malaria and reduced nitric oxide (NO) production. To better define the relationships between IL-12, NO, malaria parasitemia, and IL12B polymorphisms during malarial tolerance, plasma IL-12 levels and peripheral blood mononuclear cell NO synthase (NOS) activity were measured in asymptomatic Papua New Guineans exposed to intense malaria transmission. The IL-12 level was strongly inversely correlated with the density of Plasmodium falciparum parasitemia (rho = -0.45; P < 0.001) and was predicted to decrease by 19% (95% confidence interval [CI], 10 to 27%) for each twofold increase in P. falciparum parasitemia. This is consistent with a suppressive effect of parasitemia on IL-12 production, an effect previously shown in vitro and in rodent models of disease. The IL-12 level was inversely correlated with NOS activity (r = -0.22; P = 0.007), with each twofold increase in NOS activity being predictive of a 25% (95% CI, 7 to 38%) decrease in plasma IL-12 levels. This probably reflects additional down-regulation of IL-12 by the high basal NO production and monocyte NOS expression found in the malaria-tolerant state. Neither the IL-12 level nor NOS activity was associated with either of two IL12B polymorphisms, reflecting the diversity of genetic control over immune responses in different populations.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/14573655-10395683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14573655-10456963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14573655-10858202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14573655-10950804,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/14573655-11418654,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/14573655-11447263,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/14573655-7650384,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/14573655-9862342
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0019-9567
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pubmed:author |
pubmed-author:AnsteyNicholas MNM,
pubmed-author:BockarieMoses JMJ,
pubmed-author:BoutlisCraig SCS,
pubmed-author:ChaisavaneeyakornSujittraS,
pubmed-author:LagogMosesM,
pubmed-author:MgoneCharles SCS,
pubmed-author:MisukonisMary AMA,
pubmed-author:MorahanGrantG,
pubmed-author:UdhayakumarVenkatachalamV,
pubmed-author:WangZhiqiangZ,
pubmed-author:WeinbergJ BriceJB
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pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6354-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:14573655-Adolescent,
pubmed-meshheading:14573655-Adult,
pubmed-meshheading:14573655-Child,
pubmed-meshheading:14573655-Child, Preschool,
pubmed-meshheading:14573655-Humans,
pubmed-meshheading:14573655-Infant,
pubmed-meshheading:14573655-Interleukin-12,
pubmed-meshheading:14573655-Leukocytes, Mononuclear,
pubmed-meshheading:14573655-Malaria, Falciparum,
pubmed-meshheading:14573655-Nitric Oxide,
pubmed-meshheading:14573655-Nitric Oxide Synthase,
pubmed-meshheading:14573655-Papua New Guinea,
pubmed-meshheading:14573655-Parasitemia
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pubmed:year |
2003
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pubmed:articleTitle |
Plasma interleukin-12 in malaria-tolerant papua new guineans: inverse correlation with Plasmodium falciparum parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity.
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pubmed:affiliation |
International Health Program, Division of Infectious Diseases, Menzies School of Health Research, Northern Territory University, Flinders University Northern Territory Clinical School, Darwin, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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