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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1993-1-14
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pubmed:abstractText |
During the period 1974-89, 169 children with Hodgkin's disease were treated in the Paediatric Oncology Units of the Royal Marsden and St Bartholomew's Hospitals. The overall actuarial survival for the whole group was 81% at 10 years. Thirty-five of the 169 children either did not achieve a complete remission or subsequently relapsed. The estimated actuarial survival from initial relapse or failure of primary treatment was 60% at 5 years and 45% at 10 years. Over half of the patients requiring salvage therapy had declared themselves within 2 years and only 3 relapses occurred more than 3 years from diagnosis. Very few patients remain disease free long term after failure of primary and initial salvage therapy. Patients relapsing within a year of diagnosis or not achieving a complete response to primary therapy and those with disseminated relapse had a poor response to salvage therapy. A significant subgroup of patients had prolonged survival despite multiple relapses. Neither initial histology nor stage affected survival from relapse although numbers in each subgroup were small.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457357-2261421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457357-2313331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457357-2765370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457357-3042601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457357-3305793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457357-3311358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457357-4052932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457357-435366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457357-6546191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457357-6687379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457357-6699666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457357-7074584
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1155-8
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1457357-Actuarial Analysis,
pubmed-meshheading:1457357-Adolescent,
pubmed-meshheading:1457357-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:1457357-Child,
pubmed-meshheading:1457357-Female,
pubmed-meshheading:1457357-Hodgkin Disease,
pubmed-meshheading:1457357-Humans,
pubmed-meshheading:1457357-Male,
pubmed-meshheading:1457357-Prognosis,
pubmed-meshheading:1457357-Radiotherapy Dosage,
pubmed-meshheading:1457357-Recurrence,
pubmed-meshheading:1457357-Remission Induction,
pubmed-meshheading:1457357-Treatment Outcome
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pubmed:year |
1992
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pubmed:articleTitle |
Outcome of children with resistant and relapsed Hodgkin's disease.
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pubmed:affiliation |
Department of Paediatric Oncology, St Bartholomew's Hospital, West Smithfield, London, UK.
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pubmed:publicationType |
Journal Article
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