| pubmed-article:14573534 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14573534 | lifeskim:mentions | umls-concept:C1418915 | lld:lifeskim |
| pubmed-article:14573534 | lifeskim:mentions | umls-concept:C0231024 | lld:lifeskim |
| pubmed-article:14573534 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:14573534 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:14573534 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:14573534 | lifeskim:mentions | umls-concept:C1417735 | lld:lifeskim |
| pubmed-article:14573534 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:14573534 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:14573534 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:14573534 | lifeskim:mentions | umls-concept:C0205485 | lld:lifeskim |
| pubmed-article:14573534 | pubmed:issue | 29 | lld:pubmed |
| pubmed-article:14573534 | pubmed:dateCreated | 2003-10-23 | lld:pubmed |
| pubmed-article:14573534 | pubmed:abstractText | In developing neural tube, the basic helix-loop-helix (bHLH) transcription factor Olig2 interacts with the homeodomain transcription factor Nkx2.2 at two distinct stages. During neuronogenesis, a cross-repressive interaction appears to establish the precise boundary between the p3 and pMN domains. At later times, a cooperative interaction is noted because Nkx2.2 promotes maturation of oligodendrocyte progenitor cells specified by expression of Olig2. We show here that the Olig2 protein can form a physical complex with Nkx2.2 protein in mammalian cells and yeast two-hybrid trap assay. This interaction is specific because Olig2 does not bind to a biologically irrelevant homeodomain transcription factor (Nkx6.1), and Nkx2.2 does not interact with a biologically irrelevant bHLH protein (NeuroD). Deletion mapping analysis suggests that formation of an Olig2-Nkx2.2 physical complex is insufficient for the induction of oligodendrocyte progenitors in developing spine; however, the protein-protein interaction observed might be important for the cross-repressive interaction between Olig2 and Nkx2.2 that helps to establish the pMN-p3 boundary in the developing spinal cord. | lld:pubmed |
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| pubmed-article:14573534 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:14573534 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14573534 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14573534 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:14573534 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:14573534 | pubmed:author | pubmed-author:RowitchDavid... | lld:pubmed |
| pubmed-article:14573534 | pubmed:author | pubmed-author:KaneMichaelM | lld:pubmed |
| pubmed-article:14573534 | pubmed:author | pubmed-author:SunTaoT | lld:pubmed |
| pubmed-article:14573534 | pubmed:author | pubmed-author:StilesCharles... | lld:pubmed |
| pubmed-article:14573534 | pubmed:author | pubmed-author:WuLiziL | lld:pubmed |
| pubmed-article:14573534 | pubmed:author | pubmed-author:DongHualingH | lld:pubmed |
| pubmed-article:14573534 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:14573534 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:14573534 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:14573534 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14573534 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14573534 | pubmed:pagination | 9547-56 | lld:pubmed |
| pubmed-article:14573534 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:14573534 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14573534 | pubmed:articleTitle | Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex. | lld:pubmed |
| pubmed-article:14573534 | pubmed:affiliation | Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA. | lld:pubmed |
| pubmed-article:14573534 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14573534 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14573534 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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