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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
11
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pubmed:dateCreated |
2003-10-23
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pubmed:abstractText |
A novel series of eight dibenzoylmethane derivatives having both sunscreen and cytotoxic activity has been obtained by derivatizing commercial dibenzoyl methanes. Four human cancer cell lines (MCF 7 (breast), NCI ADR (breast expressing the multidrug resistance phenotype), NCI 460 (lung) and UACC 62 (melanoma)) were used for the cytotoxic assay. Eight among the 19 dibenzoylmethane derivatives showed cytotoxicity against these four cell lines. Absorption spectroscopies revealed that these compounds can be used as sunscreens against UV radiation.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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|
pubmed:issn |
0014-827X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1163-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14572867-Antineoplastic Agents,
pubmed-meshheading:14572867-Benzoates,
pubmed-meshheading:14572867-Cell Line, Tumor,
pubmed-meshheading:14572867-Chalcones,
pubmed-meshheading:14572867-Dose-Response Relationship, Drug,
pubmed-meshheading:14572867-Drug Screening Assays, Antitumor,
pubmed-meshheading:14572867-Humans,
pubmed-meshheading:14572867-Melanoma,
pubmed-meshheading:14572867-Skin Neoplasms,
pubmed-meshheading:14572867-Sunscreening Agents
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|
pubmed:year |
2003
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|
pubmed:articleTitle |
A novel sunscreen agent having antimelanoma activity.
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|
pubmed:affiliation |
Instituto de Química, Universidade Estadual de Campinas, CP 6154, SP, 13083-970 Campinas, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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