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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1993-1-12
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pubmed:abstractText |
The effects of high and low urine flow rates on the urinary metabolic ratios for paracetamol glucuronidation, sulphation and oxidation were determined at steady-state in seven healthy young adult volunteers. Metabolic partial clearances were unaffected by urine flow rate, but individual paracetamol metabolic ratios varied 2.5- to 3.2-fold over a 7.4-fold range of urine flow rates (0.81-6.00 ml min-1). The change in metabolic ratios was due entirely to a 2.5-fold change in renal clearance of unchanged paracetamol. These data emphasise the limitations of the metabolic ratio as a measure of intrinsic clearance for compounds which undergo some degree of tubular reabsorption.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457270-1164821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457270-1768572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457270-2049248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457270-2188267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457270-2257860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457270-2311340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457270-2611086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457270-2744070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457270-2868742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457270-3556375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457270-3790400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457270-4064464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457270-499318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457270-6121166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457270-6416284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457270-6489416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457270-6744682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457270-7039926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1457270-71400
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0306-5251
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
359-62
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
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pubmed:year |
1992
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pubmed:articleTitle |
Perturbation of paracetamol urinary metabolic ratios by urine flow rate.
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pubmed:affiliation |
Department of Clinical Pharmacology, Flinders Medical Centre, Adelaide, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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