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| pubmed-article:14572659 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14572659 | pubmed:dateCreated | 2003-10-23 | lld:pubmed |
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| pubmed-article:14572659 | pubmed:abstractText | Previous studies suggest that localization of tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family members is important for regulating their signal transduction. During a screen for TRAF3-associated proteins that potentially alter TRAF3 subcellular localization and enable signal transduction, we identified a novel protein, T3JAM (TRAF3-interacting Jun N-terminal kinase (JNK)-activating modulator). This protein associates specifically with TRAF3 but not other TRAF family members. Coexpression of T3JAM with TRAF3 recruits TRAF3 to the detergent-insoluble fraction. More importantly, T3JAM and TRAF3 synergistically activate JNK but not nuclear factor (NF)-kappaB. Our studies indicate that T3JAM may function as an adapter molecule that specifically regulates TRAF3-mediated JNK activation. | lld:pubmed |
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| pubmed-article:14572659 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:14572659 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14572659 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14572659 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:14572659 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:14572659 | pubmed:author | pubmed-author:ChengGenhongG | lld:pubmed |
| pubmed-article:14572659 | pubmed:author | pubmed-author:DadgostarHaji... | lld:pubmed |
| pubmed-article:14572659 | pubmed:author | pubmed-author:DoyleSean ESE | lld:pubmed |
| pubmed-article:14572659 | pubmed:author | pubmed-author:ShahangianAra... | lld:pubmed |
| pubmed-article:14572659 | pubmed:author | pubmed-author:GarciaDaniel... | lld:pubmed |
| pubmed-article:14572659 | pubmed:issnType | Print | lld:pubmed |
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| pubmed-article:14572659 | pubmed:volume | 553 | lld:pubmed |
| pubmed-article:14572659 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14572659 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14572659 | pubmed:pagination | 403-7 | lld:pubmed |
| pubmed-article:14572659 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:14572659 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14572659 | pubmed:articleTitle | T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK(1). | lld:pubmed |
| pubmed-article:14572659 | pubmed:affiliation | Medical Scientist Training Program, University of California Los Angeles, Los Angeles, CA 90095, USA. | lld:pubmed |
| pubmed-article:14572659 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14572659 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14572659 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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