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rdf:type |
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lifeskim:mentions |
umls-concept:C0033414,
umls-concept:C0033684,
umls-concept:C0205314,
umls-concept:C0295022,
umls-concept:C0679622,
umls-concept:C1150587,
umls-concept:C1367731,
umls-concept:C1420888,
umls-concept:C1705632,
umls-concept:C1823476,
umls-concept:C1879547
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pubmed:issue |
3
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pubmed:dateCreated |
2003-10-23
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pubmed:databankReference |
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pubmed:abstractText |
Previous studies suggest that localization of tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family members is important for regulating their signal transduction. During a screen for TRAF3-associated proteins that potentially alter TRAF3 subcellular localization and enable signal transduction, we identified a novel protein, T3JAM (TRAF3-interacting Jun N-terminal kinase (JNK)-activating modulator). This protein associates specifically with TRAF3 but not other TRAF family members. Coexpression of T3JAM with TRAF3 recruits TRAF3 to the detergent-insoluble fraction. More importantly, T3JAM and TRAF3 synergistically activate JNK but not nuclear factor (NF)-kappaB. Our studies indicate that T3JAM may function as an adapter molecule that specifically regulates TRAF3-mediated JNK activation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
553
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
403-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14572659-Amino Acid Sequence,
pubmed-meshheading:14572659-Animals,
pubmed-meshheading:14572659-Cell Line,
pubmed-meshheading:14572659-Enzyme Activation,
pubmed-meshheading:14572659-Humans,
pubmed-meshheading:14572659-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:14572659-Mice,
pubmed-meshheading:14572659-Mice, Inbred C57BL,
pubmed-meshheading:14572659-Microtubule-Associated Proteins,
pubmed-meshheading:14572659-Mitogen-Activated Protein Kinases,
pubmed-meshheading:14572659-Molecular Sequence Data,
pubmed-meshheading:14572659-Organ Specificity,
pubmed-meshheading:14572659-Protein Structure, Tertiary,
pubmed-meshheading:14572659-Proteins,
pubmed-meshheading:14572659-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:14572659-Sequence Homology, Amino Acid,
pubmed-meshheading:14572659-Signal Transduction,
pubmed-meshheading:14572659-Subcellular Fractions,
pubmed-meshheading:14572659-Substrate Specificity,
pubmed-meshheading:14572659-TNF Receptor-Associated Factor 3,
pubmed-meshheading:14572659-Transfection,
pubmed-meshheading:14572659-Two-Hybrid System Techniques
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pubmed:year |
2003
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pubmed:articleTitle |
T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK(1).
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pubmed:affiliation |
Medical Scientist Training Program, University of California Los Angeles, Los Angeles, CA 90095, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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