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rdf:type |
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lifeskim:mentions |
umls-concept:C0013935,
umls-concept:C0018956,
umls-concept:C0030274,
umls-concept:C0079429,
umls-concept:C0208973,
umls-concept:C0431693,
umls-concept:C1417951,
umls-concept:C1420636,
umls-concept:C1514562,
umls-concept:C1517892,
umls-concept:C1704666,
umls-concept:C1720950,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221,
umls-concept:C2348633
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pubmed:issue |
24
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pubmed:dateCreated |
2003-12-3
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pubmed:abstractText |
During pancreatic organogenesis endocrine cells arise from non self-renewing progenitors that express Ngn3. The precursors that give rise to Ngn3+ cells are presumably located within duct-like structures. However, the nature of such precursors is poorly understood. We show that, at E13-E18, the embryonic stage during which the major burst of beta-cell neogenesis takes place, pancreatic duct cells express Hnf1beta, the product of the maturity-onset diabetes of the young type 5 (MODY5) gene. Ngn3+ cells at this stage invariably cluster with mitotically competent Hnf1beta+ cells, and are often intercalated with these cells in the epithelium that lines the lumen of primitive ducts. We present several observations that collectively indicate that Hnf1beta+ cells are the immediate precursors of Ngn3+ cells. We furthermore show that Hnf1beta expression is markedly reduced in early pancreatic epithelial cells of Hnf6-deficient mice, in which formation of Ngn3+ cells is defective. These findings define a precursor cellular stage of the embryonic pancreas and place Hnf1beta in a genetic hierarchy that regulates the generation of pancreatic endocrine cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Nuclear Factor 1-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Nuclear Factor 6,
http://linkedlifedata.com/resource/pubmed/chemical/Hnf1b protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neurog3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Onecut1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0964-6906
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3307-14
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pubmed:dateRevised |
2009-11-24
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pubmed:meshHeading |
pubmed-meshheading:14570708-Animals,
pubmed-meshheading:14570708-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:14570708-Cell Lineage,
pubmed-meshheading:14570708-DNA-Binding Proteins,
pubmed-meshheading:14570708-Epithelial Cells,
pubmed-meshheading:14570708-Hepatocyte Nuclear Factor 1-beta,
pubmed-meshheading:14570708-Hepatocyte Nuclear Factor 6,
pubmed-meshheading:14570708-Homeodomain Proteins,
pubmed-meshheading:14570708-Mice,
pubmed-meshheading:14570708-Models, Biological,
pubmed-meshheading:14570708-Nerve Tissue Proteins,
pubmed-meshheading:14570708-Pancreas,
pubmed-meshheading:14570708-Trans-Activators,
pubmed-meshheading:14570708-Transcription Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas.
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pubmed:affiliation |
Endocrinology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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