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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2003-10-21
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pubmed:abstractText |
Th cell differentiation is a critical event in the adaptive immune response. C57BL strains develop predominant Th1 responses while BALB/c develops a predominant Th2 response. To identify quantitative trait loci controlling this variation, we performed Th1/Th2 differentiation assays of F(1) x BALB/c progeny. A single strong quantitative trait locus was identified on chromosome 18, with weaker effects detectable on chromosomes 5, 12, and 14. By preparing a congenic BALB.B10.D2c18 strain, we were able to demonstrate that this single locus was sufficient to "repolarize" spleen cell cultures. This difference was not due to intrinsic differences in CD4(+) T cells. Rather, introgression of the chromosome 18 locus into BALB/c disrupted Va14Ja18 NKT cell homeostasis resulting in the almost complete absence of this T cell subset. Taken together, these data indicate that genes within chromosome 18 control strain-dependent development of Va14Ja18 NKT cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
171
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4613-20
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:14568935-Animals,
pubmed-meshheading:14568935-Antigens, CD1,
pubmed-meshheading:14568935-Antigens, CD1d,
pubmed-meshheading:14568935-Cell Differentiation,
pubmed-meshheading:14568935-Cells, Cultured,
pubmed-meshheading:14568935-Chromosome Mapping,
pubmed-meshheading:14568935-Crosses, Genetic,
pubmed-meshheading:14568935-Genetic Linkage,
pubmed-meshheading:14568935-Heterozygote Detection,
pubmed-meshheading:14568935-Homeostasis,
pubmed-meshheading:14568935-Immunophenotyping,
pubmed-meshheading:14568935-Interleukin-4,
pubmed-meshheading:14568935-Killer Cells, Natural,
pubmed-meshheading:14568935-Lymphocyte Depletion,
pubmed-meshheading:14568935-Mice,
pubmed-meshheading:14568935-Mice, Congenic,
pubmed-meshheading:14568935-Mice, Inbred BALB C,
pubmed-meshheading:14568935-Mice, Inbred C57BL,
pubmed-meshheading:14568935-Mice, Inbred DBA,
pubmed-meshheading:14568935-Mice, Knockout,
pubmed-meshheading:14568935-Quantitative Trait Loci,
pubmed-meshheading:14568935-Spleen,
pubmed-meshheading:14568935-T-Lymphocyte Subsets,
pubmed-meshheading:14568935-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:14568935-Th1 Cells,
pubmed-meshheading:14568935-Th2 Cells
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pubmed:year |
2003
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pubmed:articleTitle |
A murine locus on chromosome 18 controls NKT cell homeostasis and Th cell differentiation.
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pubmed:affiliation |
Division of Rheumatology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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