Linked Life Data

1456881

Source:http://linkedlifedata.com/resource/pubmed/id/1456881

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1993-1-6
pubmed:abstractText
Human atherosclerosis requires decades to develop spontaneously, and its development customarily is not monitored by serial biopsies. Atherosclerosis in allografts develops within months, and biopsy specimens are usually obtained from the grafts. We have used immunocytochemical techniques to study biopsy specimens of cardiac and renal allografts for parameters of vascular changes. The antibodies used in this investigation were specific for T lymphocytes, macrophages, IgM, and complement, and detailed studies were done with the use of antibodies specific for components of the hemostatic, fibrinolytic, and natural anticoagulant pathways. The results indicated a lack of association between the appearance of cellular infiltrates and measurable alterations in vascular endothelium and smooth-muscle cells. Although infiltrating macrophages and lymphocytes were identified in biopsy specimens with vascular change, such changes were also observed in biopsy specimens that were devoid of cellular infiltrates. The most prominent vascular changes in endothelium and smooth-muscle cells were accelerated hemostasis, depressed fibrinolysis, and deranged anticoagulant pathways. A negative association between the presence of IgM and fibrin on endothelial cells was also identified. Whether vascular changes are due to immunologically mediated reactions or to as yet undefined metabolic stresses of the graft-host relationship remains to be determined. This study provides a model for the study of vascular changes in atheroma development as viewed through the window of transplant-induced atherosclerosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0003-9985
pubmed:author
pubmed:issnType
Print
pubmed:volume
116
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1337-44
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Vascular immunopathology and atheroma development in human allografted organs.
pubmed:affiliation
Department of Research, Methodist Hospital of Indiana, Indianapolis 46206-1367.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't