| pubmed-article:14568551 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14568551 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:14568551 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:14568551 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:14568551 | lifeskim:mentions | umls-concept:C1956101 | lld:lifeskim |
| pubmed-article:14568551 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:14568551 | lifeskim:mentions | umls-concept:C1366765 | lld:lifeskim |
| pubmed-article:14568551 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:14568551 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:14568551 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:14568551 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:14568551 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:14568551 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:14568551 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:14568551 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:14568551 | pubmed:dateCreated | 2003-10-21 | lld:pubmed |
| pubmed-article:14568551 | pubmed:abstractText | Luteinizing hormone (LH) induces maturational processes in oocyte-cumulus cell complexes (OCC) of preovulatory follicles that include both resumption of meiosis in the oocyte and expansion (mucification) of the cumulus oophorus. Both processes require activation of mitogen-activated protein kinase (MAPK) in granulosa cells. Here, it is reported that inhibition of MAPK activation prevented gonadotropin-stimulated resumption of meiosis as well as the rise in expression of two genes whose products are necessary for normal cumulus expansion, Has2 and Ptgs2. However, inhibition of MAPK did not block gonadotropin-induced elevation of granulosa cell cAMP, indicating that the activation of MAPK required for inducing GVB and cumulus expansion is downstream of cAMP. Moreover, activation of MAPK in cumulus cells requires one or more paracrine factors from the oocyte to induce GVB and cumulus expansion; MAPK activation alone is not sufficient to initiate these maturational processes. This study demonstrates a remarkable interaction between the oocyte and cumulus cells that is essential for gonadotropin-induced maturational processes in OCC. By enabling gonadotropin-dependent MAPK activation in granulosa cells, oocytes promote the generation of a return signal from these cells that induces the resumption of meiosis. It also appears that an oocyte-dependent pathway downstream from oocyte-enabled activation of MAPK, and distinct from that promoting the resumption of meiosis, governs cumulus expansion. | lld:pubmed |
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| pubmed-article:14568551 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14568551 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14568551 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14568551 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14568551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14568551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14568551 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14568551 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14568551 | pubmed:issn | 0012-1606 | lld:pubmed |
| pubmed-article:14568551 | pubmed:author | pubmed-author:O'BrienMarily... | lld:pubmed |
| pubmed-article:14568551 | pubmed:author | pubmed-author:WigglesworthK... | lld:pubmed |
| pubmed-article:14568551 | pubmed:author | pubmed-author:EppigJohn JJJ | lld:pubmed |
| pubmed-article:14568551 | pubmed:author | pubmed-author:DenegreJames... | lld:pubmed |
| pubmed-article:14568551 | pubmed:author | pubmed-author:PendolaFrank... | lld:pubmed |
| pubmed-article:14568551 | pubmed:author | pubmed-author:SuYou-QiangYQ | lld:pubmed |
| pubmed-article:14568551 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14568551 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:14568551 | pubmed:volume | 263 | lld:pubmed |
| pubmed-article:14568551 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14568551 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14568551 | pubmed:pagination | 126-38 | lld:pubmed |
| pubmed-article:14568551 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:14568551 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14568551 | pubmed:articleTitle | Oocyte-dependent activation of mitogen-activated protein kinase (ERK1/2) in cumulus cells is required for the maturation of the mouse oocyte-cumulus cell complex. | lld:pubmed |
| pubmed-article:14568551 | pubmed:affiliation | The Jackson Laboratory, Bar Harbor, ME 04609, USA. | lld:pubmed |
| pubmed-article:14568551 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14568551 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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