Linked Life Data

1456659

Source:http://linkedlifedata.com/resource/pubmed/id/1456659

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1993-1-7
pubmed:abstractText
At micromolar concentrations, PAF causes intense excitation and elevation of intracellular Ca in a subset of myenteric neurons. When applied for more than about 10 seconds, these concentrations of PAF kill a subset of myenteric neurons. The excitation and elevation of Ca levels are accompanied by increased membrane conductance and enhanced synaptic activity. The effects of brief applications are reversible, but responses to subsequent applications of PAF are substantially reduced. If such responses can be elicited in enteric neurons by the concentrations of PAF that are generated in vivo, they would account for the potent ability of PAF to evoke neurally-mediated secretory responses in GI tissues.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
664
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
284-92
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Excitatory and neurotoxic actions of platelet-activating factor on rat myenteric neurons in cell culture.
pubmed:affiliation
Department of Physiology, University of North Carolina, Chapel Hill 27599-7545.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.