|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001383,
umls-concept:C0028621,
umls-concept:C0028953,
umls-concept:C0037633,
umls-concept:C0205390,
umls-concept:C0220781,
umls-concept:C0439851,
umls-concept:C1382100,
umls-concept:C1552596,
umls-concept:C1883254,
umls-concept:C1947931
|
|
pubmed:issue |
5-8
|
|
pubmed:dateCreated |
2003-10-20
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|
pubmed:abstractText |
The synthesis of 3'- and 5'-O-levulinyl nucleosidic monomers through enzymatic acylation with acetonoxime levulinate is demonstrated. The acylation process takes place in one-step and use of expensive reagents, such as DMTrCl is avoided. The regioselectivity of the procedure makes it very convenient for acylated monomers required for solution phase synthesis of oligonucleotides.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1525-7770
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
22
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1455-7
|
|
pubmed:meshHeading |
|
|
pubmed:articleTitle |
Direct regioselective enzymatic acylation of nucleosides: building-blocks for the solution phase synthesis of oligonucleotides.
|
|
pubmed:affiliation |
Departamento de Química Orgánica e Inorgánica, Facultad de Química, Universidad de Oviedo, Oviedo, Spain.
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|
pubmed:publicationType |
Journal Article
|
