14562120

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0023418, umls-concept:C0030853, umls-concept:C0031525, umls-concept:C0087111, umls-concept:C0556656, umls-concept:C0684224, umls-concept:C1707689
pubmed:issue	12
pubmed:dateCreated	2003-12-12
pubmed:abstractText	Novel approaches have been designed to treat leukemia based on our understanding of the genetic and biochemical lesions present in different malignancies. This meeting report summarizes some of the recent advances in leukemia treatment. Based on the discoveries of cellular oncogenes, chromosomal translocations, monoclonal antibodies, multidrug resistance pumps, signal transduction pathways, genomics/proteonomic approaches to clinical diagnosis and mutations in biochemical pathways, clinicians and basic scientists have been able to identify the particular genetic mutations and signal transduction pathways involved as well as design more appropriate treatments for the leukemia patient. This meeting report discusses these exciting new therapies and the results obtained from ongoing clinical trials. Furthermore, rational approaches to treat complications of tumor lysis syndrome by administration of the recombinant urate oxidase protein, also known as rasburicase, which corrects the biochemical defect present in humans, were discussed. Clearly, over the past 25 years, molecular biology and biotechnology has provided the hematologist/oncologist novel bullets in their arsenal that will allow treatment by design in leukemia.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/CA 098195, http://linkedlifedata.com/resource/pubmed/grant/CA 21765, http://linkedlifedata.com/resource/pubmed/grant/CA 29139, http://linkedlifedata.com/resource/pubmed/grant/CA 31566, http://linkedlifedata.com/resource/pubmed/grant/CA 37379, http://linkedlifedata.com/resource/pubmed/grant/CA 51001, http://linkedlifedata.com/resource/pubmed/grant/CA 51025, http://linkedlifedata.com/resource/pubmed/grant/CA 61393, http://linkedlifedata.com/resource/pubmed/grant/CA 76418, http://linkedlifedata.com/resource/pubmed/grant/CA 78824, http://linkedlifedata.com/resource/pubmed/grant/CA 86991, http://linkedlifedata.com/resource/pubmed/grant/DK 59279, http://linkedlifedata.com/resource/pubmed/grant/HL 71265, http://linkedlifedata.com/resource/pubmed/grant/K23 CA 102155
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8704895
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	0887-6924
pubmed:author	pubmed-author:BertrandF EFE, pubmed-author:DaleyG QGQ, pubmed-author:LarsonR ARA, pubmed-author:MarieJ-PJP, pubmed-author:McCubreyJ AJA, pubmed-author:PorcuPP, pubmed-author:PuiC-HCH, pubmed-author:SchifferC ACA, pubmed-author:SteelmanL SLS
pubmed:issnType	Print
pubmed:volume	17
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2358-82
pubmed:dateRevised	2007-11-14
pubmed:meshHeading	pubmed-meshheading:14562120-Antineoplastic Agents, pubmed-meshheading:14562120-Humans, pubmed-meshheading:14562120-Leukemia, pubmed-meshheading:14562120-Medical Oncology
pubmed:year	2003
pubmed:articleTitle	Treatment by design in leukemia, a meeting report, Philadelphia, Pennsylvania, December 2002.
pubmed:affiliation	Section of Hematology/Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
pubmed:publicationType	Research Support, U.S. Gov't, P.H.S., Congresses, Research Support, Non-U.S. Gov't