Source:http://linkedlifedata.com/resource/pubmed/id/14561427
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2003-10-16
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| pubmed:abstractText |
A pertinent question in biological psychiatry is what differentiates responders and non-responders to pharmacological treatment. One possibility is that individual differences in the symptomatic spectrum as well as in the underlying biology of the disorder lead to the known 40% failure in pharmacological treatment. Our study aimed to maximize individual brain markers of obsessive-compulsive disorder (OCD) by applying single photon emission computed tomography (SPECT) during a provoked symptomatic state prior to and following treatment. Four brain SPECT scans were obtained from 26 OCD patients prior to and at 6 months of sertraline treatment. At each time point, two SPECT scans were performed in a counterbalanced order of two specific states; one a symptom-provoking condition and the other a relaxed condition. At 6 months of treatment, patients were divided into responders and non-responders according to a predetermined clinical criterion. Prospective responders showed significantly lower brain perfusion in the dorsal-caudal anterior cingulum and higher brain perfusion in the right caudate, when compared to non-responders, only during symptom provocation. When pre- and post-treatment scans during symptom provocation were compared, only responders showed significant change in brain response: increased perfusion in the left anterior temporal cortex and prefrontal cortex at 6 months' treatment. These findings suggest that obtaining functional brain imaging during specific symptom provocation emphasizes individual differences in brain reactivity. Thus can indicate prospective responders to symptom-related treatment in OCD and mark the relevant brain regions for effective response to treatment.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0165-1781
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
30
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| pubmed:volume |
124
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
87-103
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| pubmed:dateRevised |
2008-4-17
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| pubmed:meshHeading |
pubmed-meshheading:14561427-Adult,
pubmed-meshheading:14561427-Arousal,
pubmed-meshheading:14561427-Caudate Nucleus,
pubmed-meshheading:14561427-Cerebral Cortex,
pubmed-meshheading:14561427-Cues,
pubmed-meshheading:14561427-Dose-Response Relationship, Drug,
pubmed-meshheading:14561427-Drug Administration Schedule,
pubmed-meshheading:14561427-Female,
pubmed-meshheading:14561427-Gyrus Cinguli,
pubmed-meshheading:14561427-Humans,
pubmed-meshheading:14561427-Male,
pubmed-meshheading:14561427-Middle Aged,
pubmed-meshheading:14561427-Obsessive-Compulsive Disorder,
pubmed-meshheading:14561427-Personality Inventory,
pubmed-meshheading:14561427-Prognosis,
pubmed-meshheading:14561427-Regional Blood Flow,
pubmed-meshheading:14561427-Serotonin Uptake Inhibitors,
pubmed-meshheading:14561427-Sertraline,
pubmed-meshheading:14561427-Tomography, Emission-Computed, Single-Photon,
pubmed-meshheading:14561427-Treatment Outcome
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| pubmed:year |
2003
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| pubmed:articleTitle |
Brain reactivity to specific symptom provocation indicates prospective therapeutic outcome in OCD.
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| pubmed:affiliation |
Psychiatry Department, Chaim Sheba Medical Center, Ramat Gan, Tel Hashomer, Israel. talma@tasmc.health.gov.il
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|