Linked Life Data

14561213

Source:http://linkedlifedata.com/resource/pubmed/id/14561213

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-2-18
pubmed:abstractText
Postprandial lipaemia is known to cause endothelial dysfunction, but its underlying mechanism is still under debate. The present study was undertaken to investigate the effects of postprandial lipaemia on endothelial dysfunction and oxidative stress. We measured plasma glutathione peroxidase (GSH-Px), an antioxidant enzyme, and the urinary excretion of 8-epi-prostaglandin F2alpha (8-PGF2alpha), a free radical-catalysed product from the oxidative modification of arachidonic acid, in 16 healthy subjects (mean age, 30 +/- 5 years) without major coronary risk factors. Plasma high-sensitive C-reactive protein, soluble intercellular cell-adhesion molecule-1 and vascular cell-adhesion molecule-1 were also measured. High-resolution ultrasound was used to assess the flow-mediated vasodilatation (FMD) of the brachial artery. Blood and urine samples were collected before and 2, 4 and 6 h after a standard high-fat meal (3677 J, containing 50 g of fat). Serum triacylglycerol (triglyceride) increased and FMD decreased significantly after a high-fat meal. Plasma GSH-Px significantly decreased from 27.2 +/- 12.3 microg/ml to 25.7 +/- 11.8 microg/ml (P=0.022) 2 h after the meal, and urinary excretion of 8-PGF2alpha significantly increased from 1286 +/- 1401 pg/mg of creatinine to 2197 +/- 1343 pg/mg of creatinine (P=0.014) at 4 h after the meal. However, there were no significant changes in the levels of high-sensitive C-reactive protein and adhesion molecules after a high-fat meal. In conclusion, endothelial dysfunction was observed after consuming a high-fat meal and is associated with augmented oxidative stress manifested by the depletion of serum antioxidant enzymes and increased excretion of oxidative modification products.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0143-5221
pubmed:author
pubmed:issnType
Print
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
315-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:14561213-Adult, pubmed-meshheading:14561213-Analysis of Variance, pubmed-meshheading:14561213-Biological Markers, pubmed-meshheading:14561213-Brachial Artery, pubmed-meshheading:14561213-C-Reactive Protein, pubmed-meshheading:14561213-Dietary Fats, pubmed-meshheading:14561213-Dinoprost, pubmed-meshheading:14561213-Endothelium, Vascular, pubmed-meshheading:14561213-Glutathione Peroxidase, pubmed-meshheading:14561213-Humans, pubmed-meshheading:14561213-Hyperlipidemias, pubmed-meshheading:14561213-Intercellular Adhesion Molecule-1, pubmed-meshheading:14561213-Male, pubmed-meshheading:14561213-Oxidative Stress, pubmed-meshheading:14561213-Postprandial Period, pubmed-meshheading:14561213-Regional Blood Flow, pubmed-meshheading:14561213-Triglycerides, pubmed-meshheading:14561213-Vascular Cell Adhesion Molecule-1
pubmed:year
2004
pubmed:articleTitle
Effects of oxidative stress on endothelial function after a high-fat meal.
pubmed:affiliation
Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Medical Center, Tainan, Taiwan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't