Source:http://linkedlifedata.com/resource/pubmed/id/14561163
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2003-10-16
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pubmed:abstractText |
Inflammatory bowel disease is thought to result from inappropriate activation of mucosal immune responses. Intestinal epithelial cells produce interleukin (IL)-7 that serves as a regulatory factor for IL-7 receptor (IL-7R)(+) mucosal lymphocytes. The pivotal role of mucosal IL-7/IL-7R dependent signals in the activation of mucosal immune responses that lead to the development of chronic intestinal inflammation are demonstrated. Therapeutic approaches targeting IL-7/IL-7R signal pathway may be feasible in the treatment of inflammatory bowel disease.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1568-010X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
119-23
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14561163-Animals,
pubmed-meshheading:14561163-Chronic Disease,
pubmed-meshheading:14561163-Drug Delivery Systems,
pubmed-meshheading:14561163-Humans,
pubmed-meshheading:14561163-Interleukin-7,
pubmed-meshheading:14561163-Intestinal Diseases,
pubmed-meshheading:14561163-Intestinal Mucosa,
pubmed-meshheading:14561163-Lymphoid Tissue,
pubmed-meshheading:14561163-Receptors, Interleukin-7,
pubmed-meshheading:14561163-Signal Transduction
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pubmed:year |
2003
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pubmed:articleTitle |
Therapeutic approaches to chronic intestinal inflammation by specific targeting of mucosal IL-7/IL-7R signal pathway.
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pubmed:affiliation |
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. mamoru.gast@tmd.ac.jp
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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