Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
2003-10-29
pubmed:abstractText
MutY, like many DNA base excision repair enzymes, contains a [4Fe4S]2+ cluster of undetermined function. Electrochemical studies of MutY bound to a DNA-modified gold electrode demonstrate that the [4Fe4S] cluster of MutY can be accessed in a DNA-mediated redox reaction. Although not detectable without DNA, the redox potential of DNA-bound MutY is approximately 275 mV versus NHE, which is characteristic of HiPiP iron proteins. Binding to DNA is thus associated with a change in [4Fe4S]3+/2+ potential, activating the cluster toward oxidation. Given that DNA charge transport chemistry is exquisitely sensitive to perturbations in base pair structure, such as mismatches, we propose that this redox process of MutY bound to DNA exploits DNA charge transport and provides a DNA signaling mechanism to scan for mismatches and lesions in vivo.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-10021416, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-10353811, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-10375529, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-10572185, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-1061073, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-10775318, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-10900127, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-11017050, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-11139626, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-11179804, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-11457306, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-11601969, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-11875515, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-11877410, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-11900536, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-11911468, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-11927259, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-11983330, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-12045090, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-12127450, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-12441341, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-12534293, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-12840008, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-1328155, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-1336177, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-1411536, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-1445834, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-1495996, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-1644800, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-2197596, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-2548577, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-2675965, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-2682664, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-3044611, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-3057502, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-3902079, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-4509310, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-6253795, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-6371006, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-7008034, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-7559510, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-7559523, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-7664751, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-7823963, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-8218289, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-8419300, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-8611553, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-8663135, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-8751447, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-8789150, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-8988002, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-9164479, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-9195879, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-9230919, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-9235882, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-9287157, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-9572864, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-9733691, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-9778350, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-9846876, http://linkedlifedata.com/resource/pubmed/commentcorrection/14559969-9888851
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
12543-7
pubmed:dateRevised
2010-9-20
pubmed:meshHeading
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