Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
51
pubmed:dateCreated
2003-12-15
pubmed:abstractText
Transformation mediated by the v-Abl oncoprotein, a tyrosine kinase encoded by the Abelson murine leukemia virus, is a multi-step process requiring genetic alterations in addition to expression of v-Abl. Loss of p53 or p19ARF was previously shown to be required for Abelson murine leukemia virus transformation of primary mouse embryonic fibroblasts (MEFs). By comparing gene expression patterns in primary p53-/- MEFs acutely infected with the v-Abl retrovirus, v-Abl-transformed MEF clones, and v-Abl-transformed MEF clones treated with Abl kinase inhibitor STI 571, we have identified additional genetic alterations associated with v-Abl transformation. Bcl-xL mRNA was elevated in three of five v-Abl-transformed MEF clones. In addition, elevated expression of c-Myc mRNA, caused either by c-myc gene amplification or by enhanced signaling via STAT3, was observed in five v-Abl-transformed MEF clones. The data suggest that increases in cell survival associated with Bcl-xL and increases in cell growth associated with c-Myc facilitate the transformation process dependent on constitutive mitogenic signaling by v-Abl.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
278
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
50915-22
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:14559912-Abelson murine leukemia virus, pubmed-meshheading:14559912-Animals, pubmed-meshheading:14559912-Cell Transformation, Viral, pubmed-meshheading:14559912-Clone Cells, pubmed-meshheading:14559912-DNA-Binding Proteins, pubmed-meshheading:14559912-Embryo, Mammalian, pubmed-meshheading:14559912-Fibroblasts, pubmed-meshheading:14559912-Mice, pubmed-meshheading:14559912-Mice, Knockout, pubmed-meshheading:14559912-Proto-Oncogene Proteins c-bcl-2, pubmed-meshheading:14559912-Proto-Oncogene Proteins c-myc, pubmed-meshheading:14559912-RNA, Messenger, pubmed-meshheading:14559912-STAT3 Transcription Factor, pubmed-meshheading:14559912-Signal Transduction, pubmed-meshheading:14559912-Trans-Activators, pubmed-meshheading:14559912-Tumor Suppressor Protein p53, pubmed-meshheading:14559912-Up-Regulation, pubmed-meshheading:14559912-bcl-X Protein
pubmed:year
2003
pubmed:articleTitle
Increased expression of Bcl-xL and c-Myc is associated with transformation by Abelson murine leukemia virus.
pubmed:affiliation
Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
pubmed:publicationType
Journal Article