Source:http://linkedlifedata.com/resource/pubmed/id/14558943
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0017262,
umls-concept:C0035820,
umls-concept:C0040649,
umls-concept:C0058988,
umls-concept:C0062505,
umls-concept:C0079904,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0332282,
umls-concept:C0338106,
umls-concept:C0441655,
umls-concept:C0851285,
umls-concept:C1510779,
umls-concept:C2911684
|
pubmed:issue |
10
|
pubmed:dateCreated |
2003-10-15
|
pubmed:abstractText |
Recent studies have revealed that some transcription factors may be translationally regulated by eukaryotic initiation factor-4E (eIF-4E) in human cancer. These modifications in the expression levels of the key transcription factors will alter the expression of some malignancy-related gene products at the transcriptional levels. The current study was designed to investigate the effect of eIF-4E on the expression and activity of NF-kappaB and observe how the activity level of NF-kappaB contributes, as a secondary effect, to the transcription of heparanase in human colon adenocarcinoma LS-174T cells.
|
pubmed:language |
chi
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
1000-467X
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
22
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1023-9
|
pubmed:meshHeading |
pubmed-meshheading:14558943-Adenocarcinoma,
pubmed-meshheading:14558943-Blotting, Western,
pubmed-meshheading:14558943-Cell Line, Tumor,
pubmed-meshheading:14558943-Colonic Neoplasms,
pubmed-meshheading:14558943-Eukaryotic Initiation Factor-4E,
pubmed-meshheading:14558943-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:14558943-Glucuronidase,
pubmed-meshheading:14558943-Humans,
pubmed-meshheading:14558943-NF-kappa B,
pubmed-meshheading:14558943-Transcription, Genetic
|
pubmed:year |
2003
|
pubmed:articleTitle |
[Role of eukaryotic initiation factor-4E (eIF-4E) in regulation of expression of NF-kappaB and its subsequent influence on transcription and activity of heparanase in human colon adenocarcinoma cell line].
|
pubmed:affiliation |
PLA Institute of Digestive Disease, Nanfang Hospital, The First Military Medical University, Guangzhou, Guangdong, 510515, PR China. yujiey@fimmu.edu.cn
|
pubmed:publicationType |
Journal Article,
English Abstract,
Research Support, Non-U.S. Gov't
|