Linked Life Data

14558883

Source:http://linkedlifedata.com/resource/pubmed/id/14558883

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 3
pubmed:dateCreated
2004-1-23
pubmed:abstractText
Treatment with PTH (parathyroid hormone) or a high-P(i) diet causes internalization of the type IIa sodium-dependent phosphate (Na/P(i) IIa) co-transporter from the apical membrane and its degradation in the lysosome. A dibasic amino acid motif (KR) in the third intracellular loop of the co-transporter is essential for protein's PTH-induced retrieval. To elucidate the mechanism of internalization of Na/P(i) IIa, we identified the interacting protein for the endocytic motif by yeast two-hybrid screening. We found a strong interaction of the Na/P(i) IIa co-transporter with a small protein known as the PEX19 (human peroxisomal farnesylated protein; PxF, Pex19p). PEX19 can bind to the KR motif, but not to a mutant with this motif replaced with NI residues. PEX19 is highly expressed in mouse and rat kidney. Western blot analysis indicates that PEX19 is located in the cytosolic and brush-border membrane fractions (microvilli and the subapical component). Overexpression of PEX19 stimulated the endocytosis of the Na/P(i) IIa co-transporter in opossum kidney cells in the absence of PTH. In conclusion, the present study indicates that PEX19 may be actively involved in controlling the internalization and trafficking of the Na/P(i) IIa co-transporter.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-10051604, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-10449440, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-10555567, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-10644666, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-10777694, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-10807591, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-10878247, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-11015617, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-11050158, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-11051556, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-11053470, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-11099500, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-11173999, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-11514193, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-11532115, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-11535598, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-11590176, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-11880379, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-12086597, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-12169661, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-12192091, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-2394721, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-7977794, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-8076834, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-8120016, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-8359641, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-8743494, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-9058191, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-9077540, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-9242686, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-9339377, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-9374845, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-9418908, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-9461128, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-9465116, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-9479025, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-9691018, http://linkedlifedata.com/resource/pubmed/commentcorrection/14558883-9826740
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/PEX19 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Parathyroid Hormone, http://linkedlifedata.com/resource/pubmed/chemical/Peptides, http://linkedlifedata.com/resource/pubmed/chemical/Phosphates, http://linkedlifedata.com/resource/pubmed/chemical/SLC34A1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Slc34a1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Slc34a1 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Phosphate Cotransporter..., http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Phosphate Cotransporter..., http://linkedlifedata.com/resource/pubmed/chemical/Symporters, http://linkedlifedata.com/resource/pubmed/chemical/sodium phosphate
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1470-8728
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
377
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
607-16
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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