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pubmed-article:14558093pubmed:abstractTextCell-matrix interactions regulate chondrocyte differentiation and survival. The alpha1beta1 integrin is a major collagen receptor that is expressed on chondrocytes. Mice with targeted inactivation of the integrin alpha1 gene (alpha1-KO mice) provide a model that can be used to address the role of cell-matrix interactions in cartilage homeostasis and osteoarthritis (OA) pathogenesis.lld:pubmed
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pubmed-article:14558093pubmed:articleTitleAccelerated, aging-dependent development of osteoarthritis in alpha1 integrin-deficient mice.lld:pubmed
pubmed-article:14558093pubmed:affiliationThe Scripps Research Institute, La Jolla, California, USA.lld:pubmed
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