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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2003-10-14
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pubmed:abstractText |
Cell-matrix interactions regulate chondrocyte differentiation and survival. The alpha1beta1 integrin is a major collagen receptor that is expressed on chondrocytes. Mice with targeted inactivation of the integrin alpha1 gene (alpha1-KO mice) provide a model that can be used to address the role of cell-matrix interactions in cartilage homeostasis and osteoarthritis (OA) pathogenesis.
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pubmed:grant |
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pubmed:language |
eng
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|
pubmed:journal |
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|
pubmed:citationSubset |
AIM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0004-3591
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
2873-80
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14558093-Aging,
pubmed-meshheading:14558093-Animals,
pubmed-meshheading:14558093-Cartilage,
pubmed-meshheading:14558093-Cell Death,
pubmed-meshheading:14558093-Extracellular Matrix,
pubmed-meshheading:14558093-Female,
pubmed-meshheading:14558093-Homeostasis,
pubmed-meshheading:14558093-Integrin alpha1,
pubmed-meshheading:14558093-Male,
pubmed-meshheading:14558093-Matrix Metalloproteinase 2,
pubmed-meshheading:14558093-Matrix Metalloproteinase 3,
pubmed-meshheading:14558093-Mice,
pubmed-meshheading:14558093-Mice, Inbred BALB C,
pubmed-meshheading:14558093-Mice, Knockout,
pubmed-meshheading:14558093-Osteoarthritis,
pubmed-meshheading:14558093-Severity of Illness Index
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pubmed:year |
2003
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pubmed:articleTitle |
Accelerated, aging-dependent development of osteoarthritis in alpha1 integrin-deficient mice.
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pubmed:affiliation |
The Scripps Research Institute, La Jolla, California, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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