Source:http://linkedlifedata.com/resource/pubmed/id/14557830
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2004-1-7
|
| pubmed:abstractText |
Obesity in women has been associated with a variety of factors, including genetic predisposition, social class, early age at menarche, exercise, alcohol consumption and diet. Obesity is a risk factor for the occurrence and the recurrence of breast cancer in postmenopausal women, perhaps because of increased exposure to estrogen, insulin and insulin-like growth factors (IGFs). The progesterone receptor (PR) and the steroid hormone receptor coactivator pCIP/ACTR/AIB1/TRAM1/RAC3 (AIB1) are hypothesized to mediate signaling crosstalk between these hormonal pathways. Polymorphisms in both genes have been described and their association with breast cancer risk reported. If genetic factors contribute to obesity, and the PR and AIB1 genes influence estrogenic, insulin and IGF pathways, then genetic patterns resulting from PR and AIB1 polymorphisms may be associated with obesity in postmenopausal women.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0307-0565
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
49-56
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:14557830-Adult,
pubmed-meshheading:14557830-Aged,
pubmed-meshheading:14557830-Body Mass Index,
pubmed-meshheading:14557830-Breast Neoplasms,
pubmed-meshheading:14557830-Cross-Sectional Studies,
pubmed-meshheading:14557830-Diet,
pubmed-meshheading:14557830-Energy Intake,
pubmed-meshheading:14557830-Female,
pubmed-meshheading:14557830-Genotype,
pubmed-meshheading:14557830-Humans,
pubmed-meshheading:14557830-Life Style,
pubmed-meshheading:14557830-Menarche,
pubmed-meshheading:14557830-Middle Aged,
pubmed-meshheading:14557830-Nuclear Receptor Coactivator 3,
pubmed-meshheading:14557830-Obesity,
pubmed-meshheading:14557830-Polymorphism, Genetic,
pubmed-meshheading:14557830-Postmenopause,
pubmed-meshheading:14557830-Receptors, Progesterone,
pubmed-meshheading:14557830-Regression Analysis,
pubmed-meshheading:14557830-Risk Factors,
pubmed-meshheading:14557830-Transcription Factors
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Correlates of obesity in postmenopausal women with breast cancer: comparison of genetic, demographic, disease-related, life history and dietary factors.
|
| pubmed:affiliation |
Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0639, USA. lwasserman@ucsd.edu
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|