|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2003-10-10
|
|
pubmed:abstractText |
Variations in the interleukin 4 receptor A (IL4RA) gene have been reported to be associated with atopy, asthma, and allergy, which may occur less frequently in subjects with type 1 diabetes (T1D). Since atopy shows a humoral immune reactivity pattern, and T1D results from a cellular (T lymphocyte) response, we hypothesised that alleles predisposing to atopy could be protective for T1D and transmitted less often than the expected 50% from heterozygous parents to offspring with T1D. We genotyped seven exonic single nucleotide polymorphisms (SNPs) and the -3223 C>T SNP in the putative promoter region of IL4RA in up to 3475 T1D families, including 1244 Finnish T1D families. Only the -3223 C>T SNP showed evidence of negative association (P=0.014). There was some evidence for an interaction between -3233 C>T and the T1D locus IDDM2 in the insulin gene region (P=0.001 in the combined and P=0.02 in the Finnish data set). We, therefore, cannot rule out a genetic effect of IL4RA in T1D, but it is not a major one.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1466-4879
|
|
pubmed:author |
pubmed-author:BurrenO SOS,
pubmed-author:CarsonDD,
pubmed-author:ClaytonD GDG,
pubmed-author:CuccaFF,
pubmed-author:GujaCC,
pubmed-author:HowsonJ M MJM,
pubmed-author:Ionescu-TirgovisteCC,
pubmed-author:LamA CAC,
pubmed-author:MünchMM,
pubmed-author:MaierL MLM,
pubmed-author:NutlandSS,
pubmed-author:PattersonC CCC,
pubmed-author:RønningenK SKS,
pubmed-author:SavageDD,
pubmed-author:SminkL JLJ,
pubmed-author:SmithT JTJ,
pubmed-author:ToddJ AJA,
pubmed-author:Tuomilehto-WolfEE,
pubmed-author:TuomilehtoJJ,
pubmed-author:TwellsR C JRC,
pubmed-author:UndlienD EDE,
pubmed-author:WalkerN MNM
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
4
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
469-75
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:14551599-Alleles,
pubmed-meshheading:14551599-Asthma,
pubmed-meshheading:14551599-Chromosomes, Human, Pair 16,
pubmed-meshheading:14551599-Diabetes Mellitus, Type 1,
pubmed-meshheading:14551599-European Continental Ancestry Group,
pubmed-meshheading:14551599-Exons,
pubmed-meshheading:14551599-Gene Frequency,
pubmed-meshheading:14551599-Genetic Linkage,
pubmed-meshheading:14551599-Genetic Predisposition to Disease,
pubmed-meshheading:14551599-Genetic Variation,
pubmed-meshheading:14551599-Genotype,
pubmed-meshheading:14551599-HLA Antigens,
pubmed-meshheading:14551599-Haplotypes,
pubmed-meshheading:14551599-Humans,
pubmed-meshheading:14551599-Logistic Models,
pubmed-meshheading:14551599-Polymorphism, Single Nucleotide,
pubmed-meshheading:14551599-Promoter Regions, Genetic,
pubmed-meshheading:14551599-Receptors, Interleukin-4
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene.
|
|
pubmed:affiliation |
JDRF/WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
