Linked Life Data

14551045

Source:http://linkedlifedata.com/resource/pubmed/id/14551045

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-1-12
pubmed:abstractText
We tested the hypothesis that short-term treatment of mice with Type 2 diabetes mellitus (DM) with rosiglitazone (ROSI), an agonist of peroxisome proliferator-activated receptor-gamma, ameliorates the impaired coronary arteriolar dilation by reducing oxidative stress via a mechanism unrelated to its effect on hyperglycemia and hyperinsulinemia. Control and Type 2 DM (db/db) mice were treated with ROSI (3 mg x kg(-1) x day(-1)) for 7 days, which did not significantly affect their serum concentration of glucose and insulin. Compared with controls, in db/db mice serum levels of 8-isoprostane and dihydroethydine-detectable superoxide production in carotid arteries were significantly elevated and were reduced by ROSI treatment. In coronary arterioles (diameter, approximately 80 microm) isolated from db/db mice, the reduced dilations to ACh, the nitric oxide (NO) donor NONOate, and increases in flow were significantly augmented either by in vitro administration of apocynin, an inhibitor of NAD(P)H-oxidase, or by in vivo ROSI treatment, responses that were then significantly reduced by the NO synthase inhibitor N(omega)-nitro-L-arginine methyl ester. In aortas of db/db mice, activity of SOD and catalase was reduced, whereas NAD(P)H oxidase activity was enhanced. ROSI treatment enhanced catalase and reduced NAD(P)H oxidase activity but did not affect the activity of SOD. These findings suggest that ROSI treatment enhances NO mediation of coronary arteriolar dilations due to the reduction of vascular NAD(P)H oxidase-derived superoxide production and enhancement of catalase activity. Thus, in addition to the previously revealed beneficial metabolic effects, the antioxidant action of rosiglitazone may protect coronary arteriolar function in Type 2 DM.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0363-6135
pubmed:author
pubmed:issnType
Print
pubmed:volume
286
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
H742-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:14551045-Acetylcholine, pubmed-meshheading:14551045-Adenosine, pubmed-meshheading:14551045-Animals, pubmed-meshheading:14551045-Arterioles, pubmed-meshheading:14551045-Biological Availability, pubmed-meshheading:14551045-Coronary Vessels, pubmed-meshheading:14551045-Diabetes Mellitus, Type 2, pubmed-meshheading:14551045-Disease Models, Animal, pubmed-meshheading:14551045-Hypoglycemic Agents, pubmed-meshheading:14551045-Mice, pubmed-meshheading:14551045-Mice, Inbred C57BL, pubmed-meshheading:14551045-Muscle, Smooth, Vascular, pubmed-meshheading:14551045-NG-Nitroarginine Methyl Ester, pubmed-meshheading:14551045-Nitric Oxide, pubmed-meshheading:14551045-Nitric Oxide Donors, pubmed-meshheading:14551045-Oxidative Stress, pubmed-meshheading:14551045-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:14551045-Thiazolidinediones, pubmed-meshheading:14551045-Transcription Factors, pubmed-meshheading:14551045-Vasodilation
pubmed:year
2004
pubmed:articleTitle
PPARgamma activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with Type 2 diabetes.
pubmed:affiliation
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't