Linked Life Data

14551034

Source:http://linkedlifedata.com/resource/pubmed/id/14551034

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-10-10
pubmed:abstractText
Allocation of cadaveric donor kidneys in the UK is founded on matching for HLA-A, -B and -DR, primarily at the broad specificity level. Increasing evidence shows that matching at a higher resolution and consideration of additional loci, such as HLA-C, -DQ and -DP, improves graft outcome. The aim of this study was to clarify the typical level of split specificity HLA-A, -B, -C, -DR, -DQ and allelic -DRB1 and -DQB1 mismatching in 'favourably matched' cadaveric renal transplant pairs. Two hundred and thirty-seven cadaveric donor/recipient pairs, 'favourably matched', according to United Kingdom Transplant criteria, were typed at the split specificity level for HLA-A, -B, -C and at the allele level for HLA-DRB1 and -DQB1. The level of split specificity and allele mismatching was then assessed. Overall, 66.7% of the patients had at least one HLA-C mismatch with their donors; 36.9% of those matched for HLA-B and 85.5% of those mismatched for HLA-B (P<0.0001). A broad specificity HLA-A or -B mismatch influenced the presence of an HLA-B, or HLA-A split specificity mismatch, respectively, (P<0.05) but made no significant difference to the presence of an HLA-DR split mismatch. Overall, 4.6% of the patients were mismatched for HLA-DR split specificities but 30.4% were mismatched at HLA-DQ and 50.6% had at least one HLA-DRB1 or -DQB1 allele mismatch. Considerable HLA-A, -B, -C, -DR, -DQ matching heterogeneity exists even amongst 'well matched' renal transplant patient groups. Little is known about the effects of combinations of mismatched specificities on graft survival. Thus, further investigation is merited particularly for HLA-C and -DQ mismatching.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0966-3274
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:14551034-Great Britain, pubmed-meshheading:14551034-HLA Antigens, pubmed-meshheading:14551034-HLA-A Antigens, pubmed-meshheading:14551034-HLA-B Antigens, pubmed-meshheading:14551034-HLA-C Antigens, pubmed-meshheading:14551034-HLA-DQ Antigens, pubmed-meshheading:14551034-HLA-DQ beta-Chains, pubmed-meshheading:14551034-HLA-DR Antigens, pubmed-meshheading:14551034-HLA-DRB1 Chains, pubmed-meshheading:14551034-Haplotypes, pubmed-meshheading:14551034-Histocompatibility, pubmed-meshheading:14551034-Histocompatibility Testing, pubmed-meshheading:14551034-Humans, pubmed-meshheading:14551034-Kidney Transplantation, pubmed-meshheading:14551034-Tissue Donors, pubmed-meshheading:14551034-Transplantation, Homologous, pubmed-meshheading:14551034-Transplantation, Isogeneic, pubmed-meshheading:14551034-Transplantation Immunology
pubmed:articleTitle
HLA-A, B, C, DRB1, DQB1 matching heterogeneity in 'favourably matched' kidney recipients.
pubmed:affiliation
Welsh Transplantation and Immunogenetics Laboratory, Welsh Blood Service, Ely Valley Road, Talbot Green, Pontyclun CF72 9WB, Wales, UK. tracey.rees@wbs.wales.nhs.uk
pubmed:publicationType
Journal Article, Comparative Study