Linked Life Data

14550874

Source:http://linkedlifedata.com/resource/pubmed/id/14550874

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-10-10
pubmed:abstractText
Large clinical trials have demonstrated that HMG-CoA reductase inhibitors or 'statins' greatly reduce cardiovascular-related morbidity and mortality. The beneficial effects of statins were first assumed to result from their ability to reduce cholesterol synthesis and improve serum lipid profiles. In recent years, however, numerous pleiotropic effects of statins on atherosclerotic lesions have been described. In this review, we summarize the actions of statins on different aspects of atherosclerotic plaque development. These include endothelial dysfunction, leukocyte recruitment and inflammation, smooth muscle cell activation/proliferation, and finally plaque rupture and thrombosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1568-9972
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
332-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Atherosclerosis: anti-inflammatory and immunomodulatory activities of statins.
pubmed:affiliation
Division of Cardiology, University Hospital, Foundation for Medical Research, Faculty of Medicine, 64 Avenue de la Roseraie, 1211 Geneva 4, Switzerland. brenda.kwakchanson@medicine.unige.ch
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't