| pubmed-article:14550279 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14550279 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:14550279 | lifeskim:mentions | umls-concept:C0014257 | lld:lifeskim |
| pubmed-article:14550279 | lifeskim:mentions | umls-concept:C0911014 | lld:lifeskim |
| pubmed-article:14550279 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:14550279 | lifeskim:mentions | umls-concept:C0277785 | lld:lifeskim |
| pubmed-article:14550279 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:14550279 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:14550279 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14550279 | pubmed:dateCreated | 2003-10-10 | lld:pubmed |
| pubmed-article:14550279 | pubmed:abstractText | Ghrelin is a novel growth hormone (GH)-releasing peptide which was isolated from the stomach. We have reported that ghrelin causes vasorelaxation in rats through GH-independent mechanisms. We investigated whether ghrelin improves endothelial dysfunction. Ghrelin was subcutaneously administered to GH-deficient rats for three weeks. After isolation of the thoracic aorta, aortic ring tension was measured to evaluate vasorelaxation. Acetylcholine-induced vasorelaxation was impaired in GH-deficient rats given placebo compared to that in normal rats given placebo. GH-deficient rats treated with ghrelin, however, showed a significant increase in the maximal relaxation as compared with those given placebo. This improvement by ghrelin was inhibited by N(G)-nitro-L-arginine methyl ester, a nonselective nitric oxide synthase (NOS) inhibitor. Western blot analysis demonstrated that treatment with ghrelin increased endothelial NOS (eNOS) expression in the aorta of GH-deficient rats. These results suggest that administration of ghrelin improves endothelial dysfunction and increases eNOS expression in rats through GH-independent mechanisms. | lld:pubmed |
| pubmed-article:14550279 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14550279 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14550279 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14550279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14550279 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14550279 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:14550279 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:14550279 | pubmed:author | pubmed-author:KangawaKenjiK | lld:pubmed |
| pubmed-article:14550279 | pubmed:author | pubmed-author:NagayaNoritos... | lld:pubmed |
| pubmed-article:14550279 | pubmed:author | pubmed-author:YoshizumiMasa... | lld:pubmed |
| pubmed-article:14550279 | pubmed:author | pubmed-author:KohnoNobuokiN | lld:pubmed |
| pubmed-article:14550279 | pubmed:author | pubmed-author:ImazuMichinor... | lld:pubmed |
| pubmed-article:14550279 | pubmed:author | pubmed-author:YamamotoHidey... | lld:pubmed |
| pubmed-article:14550279 | pubmed:author | pubmed-author:TeranishiYasu... | lld:pubmed |
| pubmed-article:14550279 | pubmed:author | pubmed-author:ShimizuYoshit... | lld:pubmed |
| pubmed-article:14550279 | pubmed:author | pubmed-author:ShokawaTomoki... | lld:pubmed |
| pubmed-article:14550279 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14550279 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:14550279 | pubmed:volume | 310 | lld:pubmed |
| pubmed-article:14550279 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14550279 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14550279 | pubmed:pagination | 830-5 | lld:pubmed |
| pubmed-article:14550279 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:14550279 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14550279 | pubmed:articleTitle | Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats. | lld:pubmed |
| pubmed-article:14550279 | pubmed:affiliation | Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. | lld:pubmed |
| pubmed-article:14550279 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14550279 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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