rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-10-10
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pubmed:abstractText |
Ghrelin is a novel growth hormone (GH)-releasing peptide which was isolated from the stomach. We have reported that ghrelin causes vasorelaxation in rats through GH-independent mechanisms. We investigated whether ghrelin improves endothelial dysfunction. Ghrelin was subcutaneously administered to GH-deficient rats for three weeks. After isolation of the thoracic aorta, aortic ring tension was measured to evaluate vasorelaxation. Acetylcholine-induced vasorelaxation was impaired in GH-deficient rats given placebo compared to that in normal rats given placebo. GH-deficient rats treated with ghrelin, however, showed a significant increase in the maximal relaxation as compared with those given placebo. This improvement by ghrelin was inhibited by N(G)-nitro-L-arginine methyl ester, a nonselective nitric oxide synthase (NOS) inhibitor. Western blot analysis demonstrated that treatment with ghrelin increased endothelial NOS (eNOS) expression in the aorta of GH-deficient rats. These results suggest that administration of ghrelin improves endothelial dysfunction and increases eNOS expression in rats through GH-independent mechanisms.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Cardiovascular Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Ghrelin,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin,
http://linkedlifedata.com/resource/pubmed/chemical/NG-Nitroarginine Methyl Ester,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroprusside,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Placebos
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
310
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
830-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:14550279-Acetylcholine,
pubmed-meshheading:14550279-Animals,
pubmed-meshheading:14550279-Aorta, Thoracic,
pubmed-meshheading:14550279-Arteriosclerosis,
pubmed-meshheading:14550279-Blood Pressure,
pubmed-meshheading:14550279-Blotting, Western,
pubmed-meshheading:14550279-Body Weight,
pubmed-meshheading:14550279-Cardiovascular Agents,
pubmed-meshheading:14550279-Dose-Response Relationship, Drug,
pubmed-meshheading:14550279-Endothelium, Vascular,
pubmed-meshheading:14550279-Enzyme Inhibitors,
pubmed-meshheading:14550279-Ghrelin,
pubmed-meshheading:14550279-Growth Hormone,
pubmed-meshheading:14550279-Heart Rate,
pubmed-meshheading:14550279-Indomethacin,
pubmed-meshheading:14550279-Male,
pubmed-meshheading:14550279-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:14550279-Nitric Oxide Synthase,
pubmed-meshheading:14550279-Nitroprusside,
pubmed-meshheading:14550279-Peptide Hormones,
pubmed-meshheading:14550279-Placebos,
pubmed-meshheading:14550279-Rats,
pubmed-meshheading:14550279-Rats, Sprague-Dawley
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pubmed:year |
2003
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pubmed:articleTitle |
Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats.
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pubmed:affiliation |
Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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