Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-10-10
pubmed:abstractText
Ghrelin is a novel growth hormone (GH)-releasing peptide which was isolated from the stomach. We have reported that ghrelin causes vasorelaxation in rats through GH-independent mechanisms. We investigated whether ghrelin improves endothelial dysfunction. Ghrelin was subcutaneously administered to GH-deficient rats for three weeks. After isolation of the thoracic aorta, aortic ring tension was measured to evaluate vasorelaxation. Acetylcholine-induced vasorelaxation was impaired in GH-deficient rats given placebo compared to that in normal rats given placebo. GH-deficient rats treated with ghrelin, however, showed a significant increase in the maximal relaxation as compared with those given placebo. This improvement by ghrelin was inhibited by N(G)-nitro-L-arginine methyl ester, a nonselective nitric oxide synthase (NOS) inhibitor. Western blot analysis demonstrated that treatment with ghrelin increased endothelial NOS (eNOS) expression in the aorta of GH-deficient rats. These results suggest that administration of ghrelin improves endothelial dysfunction and increases eNOS expression in rats through GH-independent mechanisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
310
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
830-5
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:14550279-Acetylcholine, pubmed-meshheading:14550279-Animals, pubmed-meshheading:14550279-Aorta, Thoracic, pubmed-meshheading:14550279-Arteriosclerosis, pubmed-meshheading:14550279-Blood Pressure, pubmed-meshheading:14550279-Blotting, Western, pubmed-meshheading:14550279-Body Weight, pubmed-meshheading:14550279-Cardiovascular Agents, pubmed-meshheading:14550279-Dose-Response Relationship, Drug, pubmed-meshheading:14550279-Endothelium, Vascular, pubmed-meshheading:14550279-Enzyme Inhibitors, pubmed-meshheading:14550279-Ghrelin, pubmed-meshheading:14550279-Growth Hormone, pubmed-meshheading:14550279-Heart Rate, pubmed-meshheading:14550279-Indomethacin, pubmed-meshheading:14550279-Male, pubmed-meshheading:14550279-NG-Nitroarginine Methyl Ester, pubmed-meshheading:14550279-Nitric Oxide Synthase, pubmed-meshheading:14550279-Nitroprusside, pubmed-meshheading:14550279-Peptide Hormones, pubmed-meshheading:14550279-Placebos, pubmed-meshheading:14550279-Rats, pubmed-meshheading:14550279-Rats, Sprague-Dawley
pubmed:year
2003
pubmed:articleTitle
Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats.
pubmed:affiliation
Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't