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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
1993-1-7
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pubmed:abstractText |
In the presence of the nucleotide analog adenosine 5'-[gamma-thio]triphosphate (ATP[gamma S]), effects of Ca2+ on stiffness and equatorial x-ray diffraction patterns of single skinned fibers of the rabbit psoas muscle were studied. It is shown that cross-bridges in the presence of ATP[gamma S] have properties of the weak-binding states of the ATP hydrolysis cycle. Raising the Ca2+ concentration up to pCa 4.5 has little effect on actin affinity of cross-bridges in the presence of ATP[gamma S]. However, the rate constants for cross-bridge dissociation and reassociation from and to actin are reduced by about 2 orders of magnitude. In addition, nucleotide affinity of the cross-bridge is much smaller at high Ca2+ concentrations. Implications for interpretation of fiber stiffness recorded during isotonic shortening and the rising phase of a tetanus are discussed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-1080798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-158378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-1835789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-2062853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-2838098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-2838100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-2930829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-2930830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-2932449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-2941026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-2952054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-2956257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-2966401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-3022835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-3156404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-3413119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-3487643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-3735425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-3872938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-4022124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-4041539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-4092069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-4261616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-5719221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-6237104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-6243280,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-6824759,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-6930656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-6961408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-6979780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1454820-6996582
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11362-6
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
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pubmed:year |
1992
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pubmed:articleTitle |
Effect of Ca2+ on weak cross-bridge interaction with actin in the presence of adenosine 5'-[gamma-thio]triphosphate).
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pubmed:affiliation |
Department of General Physiology, University of Ulm, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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