| pubmed-article:1454817 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1454817 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1454817 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1454817 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:1454817 | lifeskim:mentions | umls-concept:C0034819 | lld:lifeskim |
| pubmed-article:1454817 | lifeskim:mentions | umls-concept:C0020861 | lld:lifeskim |
| pubmed-article:1454817 | lifeskim:mentions | umls-concept:C1420192 | lld:lifeskim |
| pubmed-article:1454817 | lifeskim:mentions | umls-concept:C0162768 | lld:lifeskim |
| pubmed-article:1454817 | lifeskim:mentions | umls-concept:C1511636 | lld:lifeskim |
| pubmed-article:1454817 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:1454817 | pubmed:dateCreated | 1993-1-7 | lld:pubmed |
| pubmed-article:1454817 | pubmed:abstractText | We have constructed a hybrid cDNA coding for a fusion protein between human interleukin 2 and a truncated heavy chain from human immunoglobulin M. The protein encoded by this cDNA contains the entire interleukin 2 sequence including its signal peptide, fused at its C terminus to domains 2 to 4 of the immunoglobulin heavy-chain constant region. Cells transfected with the hybrid cDNA secrete multimeric forms of the fusion protein, which bind specifically to cells bearing high-affinity interleukin 2 receptors. This binding leads either to T-cell proliferation or, if complement is added, to T-cell death. Multimeric forms of the fusion protein with a molecular mass above 500 kDa mediate complement-dependent lysis but trigger proliferation inefficiently when compared with forms with a low molecular mass (< 500 kDa). In contrast, the latter efficiently mediate T-cell proliferation without inducing complement-dependent lysis. The high molecular mass fusion proteins could thus constitute valuable tools for specific immunosuppression in humans. | lld:pubmed |
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| pubmed-article:1454817 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1454817 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1454817 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1454817 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1454817 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1454817 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:1454817 | pubmed:author | pubmed-author:JacquesYY | lld:pubmed |
| pubmed-article:1454817 | pubmed:author | pubmed-author:BreathnachRR | lld:pubmed |
| pubmed-article:1454817 | pubmed:author | pubmed-author:GodardAA | lld:pubmed |
| pubmed-article:1454817 | pubmed:author | pubmed-author:PeyratM AMA | lld:pubmed |
| pubmed-article:1454817 | pubmed:author | pubmed-author:SoulillouJ... | lld:pubmed |
| pubmed-article:1454817 | pubmed:author | pubmed-author:DietrichJJ | lld:pubmed |
| pubmed-article:1454817 | pubmed:author | pubmed-author:KaraiKK | lld:pubmed |
| pubmed-article:1454817 | pubmed:author | pubmed-author:GauthierTT | lld:pubmed |
| pubmed-article:1454817 | pubmed:author | pubmed-author:BonnevilleMM | lld:pubmed |
| pubmed-article:1454817 | pubmed:author | pubmed-author:GesnelM CMC | lld:pubmed |
| pubmed-article:1454817 | pubmed:author | pubmed-author:ViéHH | lld:pubmed |
| pubmed-article:1454817 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1454817 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1454817 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:1454817 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1454817 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1454817 | pubmed:pagination | 11337-41 | lld:pubmed |
| pubmed-article:1454817 | pubmed:dateRevised | 2011-1-27 | lld:pubmed |
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| pubmed-article:1454817 | pubmed:meshHeading | pubmed-meshheading:1454817-... | lld:pubmed |
| pubmed-article:1454817 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1454817 | pubmed:articleTitle | Human fusion proteins between interleukin 2 and IgM heavy chain are cytotoxic for cells expressing the interleukin 2 receptor. | lld:pubmed |
| pubmed-article:1454817 | pubmed:affiliation | Institut National de la Santé et de la Recherche Médicale (U.211), Unité de Recherche sur les Effecteurs Lymphocytaires, Nantes, France. | lld:pubmed |
| pubmed-article:1454817 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1454817 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1454817 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1454817 | lld:pubmed |
