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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-10-10
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pubmed:abstractText |
Recent data in yeast and Drosophila suggest a domain-like centromere structure with a modified chromatin core and flanking regions of heterochromatin. We have analyzed a functional human centromere and defined a region of increased chromosome scaffold/matrix attachment that overlaps three other distinct and nonoverlapping domains for constitutive centromere proteins CENP-A and CENP-H, and heterochromatin protein HP1. Transcriptional competency is intact throughout the S/MAR-enriched region and within the CENP-A- and CENP-H-associated chromatin. These results provide insights into the relationship between centromeric chromatin and transcriptional competency in vivo, highlighting the permissibility of transcription within the constitutively modified, nonheterochromatic chromatin of a functional eukaryotic centromere.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/CENPH protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chromatin,
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HNF1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/HNF1B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Nuclear Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Nuclear Factor 1-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Nuclear Factor 1-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Heterochromatin,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/centromere protein A
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1097-2765
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
509-16
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pubmed:dateRevised |
2008-9-11
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pubmed:meshHeading |
pubmed-meshheading:14536089-Animals,
pubmed-meshheading:14536089-Autoantigens,
pubmed-meshheading:14536089-Centromere,
pubmed-meshheading:14536089-Chromatin,
pubmed-meshheading:14536089-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:14536089-Chromosomes, Artificial, Bacterial,
pubmed-meshheading:14536089-Chromosomes, Human, Pair 10,
pubmed-meshheading:14536089-DNA-Binding Proteins,
pubmed-meshheading:14536089-Drosophila,
pubmed-meshheading:14536089-Gene Expression Regulation,
pubmed-meshheading:14536089-Hepatocyte Nuclear Factor 1,
pubmed-meshheading:14536089-Hepatocyte Nuclear Factor 1-alpha,
pubmed-meshheading:14536089-Hepatocyte Nuclear Factor 1-beta,
pubmed-meshheading:14536089-Heterochromatin,
pubmed-meshheading:14536089-Humans,
pubmed-meshheading:14536089-Hybrid Cells,
pubmed-meshheading:14536089-Models, Genetic,
pubmed-meshheading:14536089-Nuclear Proteins,
pubmed-meshheading:14536089-Protein Binding,
pubmed-meshheading:14536089-Protein Structure, Tertiary,
pubmed-meshheading:14536089-Transcription, Genetic,
pubmed-meshheading:14536089-Transcription Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Transcription within a functional human centromere.
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pubmed:affiliation |
The Murdoch Childrens Research Institute, Royal Children's Hospital, Flemington Road, Melbourne, 3052, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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